Whether memory CD8 T cells can be reactivated in nonlymphoid tissues is unclear. Using
mice lacking the spleen, lymph nodes, or both, we show that the secondary T cell response …

Immunological memory is a hallmark of B and T lymphocytes that have undergone a
previous encounter with a given antigen. It is assumed that memory cells mediate better …

Following infection, T cells differentiate into a heterogeneous population of effector T cells
that can mediate pathogen clearance. A subset of these effector T cells possesses the ability …

Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …

T cell protective immunity is associated with multifunctional memory cells that produce
several different cytokines. Currently, our understanding of when and how these cells are …

Immunity towards intracellular pathogens is often dependent upon the generation of CD8+
memory T cells, which provide long-lasting and effective protection. Over the past few years …

In response to infection, CD8+ T cells integrate multiple signals and undergo an exponential
increase in cell numbers. Simultaneously, a dynamic differentiation process occurs, resulting …

One outcome of infection is the formation of long-lived immunological memory, which
provides durable protection from symptomatic re-infection. In response to infection or …

After vaccination, memory CD8+ T cells migrate to different organs to mediate immune
surveillance. In most nonlymphoid organs, following an infection, CD8+ T cells differentiate …

A functional memory T cell pool is critical for resistance to pathogen reinfection.
Lymphopenia produces memory-like CD8+ T cells through homeostatic proliferation, and …