Recent findings suggest a new paradigm that early inflammatory cytokines promote the
effector T‐cell response while inhibiting the development of CD8+ T‐cell memory. Although …

The adaptive immune system has evolved a unique capacity to remember a pathogen
through the generation of memory T cells, which rapidly protect the host in the event of …

A functional memory T cell pool is critical for resistance to pathogen reinfection.
Lymphopenia produces memory-like CD8+ T cells through homeostatic proliferation, and …

Immunologic memory reflects the ability of a host to more effectively respond to a re-
encounter with a particular pathogen than the first encounter, and when a vaccine mimics …

Maintenance of immunological memory has been proposed to rely on stem-cell-like
lymphocytes. However, data supporting this hypothesis are focused on the developmental …

The ability to develop and sustain populations of memory T cells after infection or
immunization is a hallmark of the adaptive immune response and a basis for protective …

In response to infection or effective vaccination, naive antigen‐specific CD8+ T cells
undergo a dramatic highly orchestrated activation process. Initial encounter with an …

Immune responses to infection are optimally designed to generate large numbers of effector
T cells while simultaneously minimizing the collateral damage of their potentially lethal …

The development of immune memory mediated by T lymphocytes is central to durable, long‐
lasting protective immunity. A key issue in the field is how to direct the generation and …

The precursor frequency of naive CD4+ T cells shows an inverse relationship with the
number of memory cells generated after exposure to cognate Ag. Using the lymphocytic …