The adaptive immune response of human CD8 T cells to invading pathogens involves the
differentiation of naive cells into memory and effector cells. However, the lineage …

CD8+ T‐cell responses must have at least two components, a replicative cell type that
proliferates in the secondary lymphoid tissue and that is responsible for clonal expansion …

Infection elicits CD4+ memory T lymphocytes that participate in protective immunity.
Although memory cells are the progeny of naïve T cells, it is unclear that all naïve cells from …

During an infection, antigen‐specific CD8+ T cells undergo numerous cellular and
transcriptional changes as they develop from naive T cells into effector and memory cells …

Viral infections have been shown to induce lymphopenias that lower memory CD8 T cell
frequencies, and they also have been shown to cause a permanent loss of memory cells …

Our knowledge about the kinetics and dynamics of complex pathogen‐specific CD8+ T cell
responses and the in vivo development of CD8+ memory T cells has increased substantially …

Memory CD8+ T cell responses have been considered to be independent of CD80/CD86-
CD28 costimulation. However, recall responses are often severely blunted in CD28−/− mice …

We have recently defined a novel population of PD-1 (programmed cell death 1)+ TCF1 (T
cell factor 1)+ virus-specific CD8 T cells that function as resource cells during chronic LCMV …

A fundamental property of the adaptive immune system is the ability to generate antigen-
specific memory, which protects against repeated infections with the same pathogens and …

Memory T cells are distributed throughout the body following infection, but the migratory
dynamics of the memory pool in vivo is unknown. The ability of circulating microbe-specific …