CD4+ T cell help during the priming of CD8+ T lymphocytes imprints the capacity for optimal
secondary expansion upon re‐encounter with antigen. Helped memory CD8+ T cells rapidly …

Memory CD8 T cells persist by Ag-independent homeostatic proliferation. To examine the
dynamics of this cell turnover, we transferred lymphocytic choriomeningitis virus specific …

Memory T cells are critical for immunity to various intracellular pathogens. Recent studies
have indicated that CD8 secondary memory cells, induced by prime-boost approaches …

CD8 T cells are pivotal for the control of many intracellular pathogens, and besides their role
in immediate control of infections, CD8 T cells have the capacity to differentiate into long …

Various signals during infection influence CD8 T cell memory generation, but these factors
have yet to be fully defined. IL-12 is a proinflammatory cytokine that has been shown to …

Mechanisms for the generation of memory CD4 T cells and their delineation into diverse
subsets remain largely unknown. In this study, we demonstrate in two Ag systems, divergent …

How and when memory T cells form during an immune response are long-standing
questions. To better understand memory CD8 T cell development, a time course of gene …

The hallmark of effective establishment of immune memory is the long‐term memory cell that
persists in the absence of antigen. To explore its characteristics, we investigated the …

Complete T cell development requires postthymic maturation, and we investigated the
influence of this ontological period on the CD8 T cell response to infection by comparing …

Prime-boost immunization is a promising strategy for inducing and amplifying pathogen-or
tumor-specific memory CD8 T cell responses. Although expansion of CD8 T cell populations …