Oxidants, including hydrogen peroxide (H2O2), have been recognized for years to mimic
insulin action on glucose transport in adipose cells. Early studies also demonstrated the …

Propelled by the identification of a small family of NADPH oxidase (Nox) enzyme homologs
that produce superoxide in response to cellular stimulation with various growth factors …

Insulin stimulation of target cells elicits a burst of H2O2 that enhances tyrosine
phosphorylation of the insulin receptor and its cellular substrate proteins as well as distal …

In a variety of cell types, insulin stimulation elicits the rapid production of H 2 O 2, which
causes the oxidative inhibition of protein-tyrosine phosphatases and enhances the tyrosine …

Hydrogen peroxide (H2O2) mimics many physiological responses of insulin, and increased
H2O2 generation via the Nox-4 subunit of NAD (P) H oxidase was recently demonstrated to …

Inflammation and oxidative stress through the production of reactive oxygen species (ROS)
are consistently associated with metabolic syndrome/type 2 diabetes. Although the role of …

Reactive oxygen species (ROS) contribute to the progression of various human diseases,
including type 2 diabetes mellitus (T2DM). ROS can suppress the insulin response and …

In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has
been reported, along with controversial findings regarding its function. Here, the role of …

Objective—Type 2 diabetes mellitus and related syndromes exhibit a deadly triad of
dyslipoproteinemia, which leads to atherosclerosis; hyperglycemia, which causes …

Reactive oxygen and nitrogen molecules have been typically viewed as the toxic by-
products of metabolism. However, accumulating evidence has revealed that reactive …