Selenium variation on a cysteine theme: Selenocysteine (Sec) has been employed in a
number of chemoselective ligations. Sec can be used for native chemical and expressed …

The convergent assembly of peptide fragments by native chemical ligation has
revolutionized the way in which proteins can be accessed by chemical synthesis. A variation …

Highlights•When selenoester is used for ligation reactions with diselenides, kinetics are
accelerated and side reactions are minimized.•Selenozolidine is emerging as the preferred …

We describe an unprecedented reaction between peptide selenoesters and peptide dimers
bearing N-terminal selenocystine that proceeds in aqueous buffer to afford native amide …

Selenocysteine, the selenium‐containing analogue of cysteine, is the twenty‐first
proteinogenic amino acid. Since its discovery almost fifty years ago, it has been exploited in …

The use of native chemical ligation at selenocysteine (Sec) residues with peptide thioesters
and additive‐free selenocystine ligation with peptides bearing phenyl selenoesters, in …

A short survey of historic and current methods for the synthesis of selenocysteine,
selenocystine, and derivatives and related compounds is presented, with an additional …

Selenocysteine (Sec) residue cannot be directly attached to a peptide sequence unless the
selenol form is protected beforehand and several problems have been reported in the …

The synthesis of suitably protected β-selenophenylalanine and β-selenoleucine amino acids
was accomplished from Garner's aldehyde as a common starting point. These selenoamino …

In recent years, researchers have been exploring the potential of incorporating selenium into
peptides, as this element possesses unique properties that can enhance the reactivity of …