Neuroprotective and neurotrophic actions of glucagon‐like peptide‐1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders

I Salcedo, D Tweedie, Y Li… - British journal of …, 2012 - Wiley Online Library
Like type‐2 diabetes mellitus (T2DM), neurodegenerative disorders and stroke are an ever
increasing, health, social and economic burden for developed Westernized countries. Age is …

Glucagon-like peptide-1: a focus on neurodegenerative diseases

M Grieco, A Giorgi, MC Gentile, M d'Erme… - Frontiers in …, 2019 - frontiersin.org
Diabetes mellitus is one of the major risk factors for cognitive dysfunction. The pathogenesis
of brain impairment caused by chronic hyperglycemia is complex and includes …

GLP-1's role in neuroprotection: a systematic review

D Erbil, CY Eren, C Demirel, MU Küçüker, I Solaroğlu… - Brain injury, 2019 - Taylor & Francis
ABSTRACT Glucagon-like peptide 1 (GLP-1) is a target for treatment of diabetes; however,
its function in the brain is not well studied. In this systematic review, we aimed to analyze the …

The role of glia in the physiology and pharmacology of glucagon‐like peptide‐1: implications for obesity, diabetes, neurodegeneration and glaucoma

QN Cui, LM Stein, SM Fortin… - British Journal of …, 2022 - Wiley Online Library
The medical applications of glucagon‐like peptide‐1 receptor (GLP‐1R) agonists is
evergrowing in scope, highlighting the urgent need for a comprehensive understanding of …

Neuroprotective properties of GLP-1: theoretical and practical applications

JJ Holst, R Burcelin, E Nathanson - Current medical research and …, 2011 - Taylor & Francis
In the past few years, the development of pharmaceutical agents that enhance the
physiological effects of glucagon-like peptide-1 (GLP-1), either through GLP-1 receptor …

Glucagon-like peptide-1 and the central/peripheral nervous system: crosstalk in diabetes

G Muscogiuri, RA DeFronzo, A Gastaldelli… - Trends in Endocrinology …, 2017 - cell.com
Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles
in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation …

Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases

SD Chen, YC Chuang, TK Lin, JL Yang - European journal of …, 2023 - Elsevier
Aging is a crucial risk factor for common neurodegenerative diseases, such as Alzheimer's
disease (AD) and Parkinson's disease (PD). Limited options are available for the treatment …

Glucagon‐like peptide‐1 (GLP‐1) signalling in the brain: From neural circuits and metabolism to therapeutics

A Kabahizi, B Wallace, L Lieu, D Chau… - British Journal of …, 2022 - Wiley Online Library
Glucagon‐like‐peptide‐1 (GLP‐1) derived from gut enteroendocrine cells and a discrete
population of neurons in the caudal medulla acts through humoral and neural pathways to …

[HTML][HTML] Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

AI Duarte, E Candeias, SC Correia, RX Santos… - … et Biophysica Acta (BBA …, 2013 - Elsevier
According to World Health Organization estimates, type 2 diabetes (T2D) is an epidemic
(particularly in under development countries) and a socio-economic challenge. This is even …

[HTML][HTML] Recent advances in understanding the role of glucagon-like peptide 1

J Reed, SC Bain, V Kanamarlapudi - F1000Research, 2020 - ncbi.nlm.nih.gov
The discovery that glucagon-like peptide 1 (GLP-1) mediates a significant proportion of the
incretin effect during the postprandial period and the subsequent observation that GLP-1 …