The molecular circuitries controlling the process of skin wound healing have gained new
significant insights in recent years. This knowledge is built on landmark studies on skin …

PhosphoInositide-3 Kinase (PI3K) represents a family of different classes of kinases which
control multiple biological processes in mammalian cells, such as cell growth, proliferation …

Background The management of slow or non-healing ulcerations constitutes an increasing
clinical challenge in the developed world because of the ageing of the population and the …

The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin
(mTOR) signaling pathway has been implicated in various immune-mediated inflammatory …

The epidermis, the outmost layer of the skin, is a stratified squamous epithelium that protects
the body from the external world. The epidermis and its appendages need constantly renew …

The mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-
inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation …

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway regulates
cell proliferation, differentiation, and migration, along with angiogenesis and metabolism …

The serine/threonine kinase mechanistic target of rapamycin (mTOR) plays a pivotal role in
the regulation of cell proliferation, survival, and motility in response to availability of energy …

Regeneration is the holy grail of tissue repair, but skin injury typically yields fibrotic, non-
functional scars. Developing pro-regenerative therapies requires rigorous understanding of …

Keratinocyte differentiation is an intricate process that is regulated by multiple mediators.
Using cultured human keratinocytes, we found that lysophosphatidic acid (LPA) induced the …