This review recounts the origins and development of the concept of the hypothalamic
gonadotropin-releasing hormone (GnRH) pulse generator. It starts in the late 1960s when …

The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …

Gonadotropin-releasing hormone (GnRH) is the ultimate output signal of an intricate network
of neuroendocrine factors that, acting on the pituitary, trigger gonadotropin release. In turn …

Gonadotropin-releasing hormone (GnRH) secretion has two modes of release in
mammalian species; the surge mode and the pulse mode. The surge mode, which is …

Gonadal steroid feedback regulates the brain's patterned secretion of gonadotropin-
releasing hormone (GnRH). Negative feedback, which occurs in males and during the …

The pulsatility of GnRH release is essential for reproductive function. The key events in
reproductive function, such as puberty onset and ovulatory cycles, are regulated by the …

There is now considerable evidence supporting the role of a subpopulation of neurons in the
arcuate nucleus of the hypothalamus that coexpress kisspeptin, neurokinin B, and dynorphin …

Ovulation is an essential phenomenon for reproduction in mammalian females along with
follicular growth. It is well established that gonadal function is controlled by the …

Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive
axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins follicle …

Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that
colocalize three neuropeptides, kisspeptin, neurokinin B, and dynorphin, each of which has …