Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway

CC Woo, SY Loo, V Gee, CW Yap, G Sethi… - Biochemical …, 2011 - Elsevier
Thymoquinone (TQ), an active ingredient of Nigella sativa, has been reported to exhibit anti-
oxidant, anti-inflammatory and anti-tumor activities through mechanism (s) that is not fully …

Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS

CC Woo, A Hsu, AP Kumar, G Sethi, KHB Tan - PloS one, 2013 - journals.plos.org
Due to narrow therapeutic window of cancer therapeutic agents and the development of
resistance against these agents, there is a need to discover novel agents to treat breast …

Thymoquinone: potential cure for inflammatory disorders and cancer

CC Woo, AP Kumar, G Sethi, KHB Tan - Biochemical pharmacology, 2012 - Elsevier
Thymoquinone is an active ingredient isolated from Nigella sativa and has been
investigated for its anti-oxidant, anti-inflammatory and anticancer activities in both in vitro …

Therapeutic implications and clinical manifestations of thymoquinone

M Alam, GM Hasan, MM Ansari, R Sharma, DK Yadav… - Phytochemistry, 2022 - Elsevier
Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has
been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and …

[HTML][HTML] Thymoquinone and its pharmacological perspective: A review

S Tabassum, N Rosli, SJA Ichwan, P Mishra - … Research-Modern Chinese …, 2021 - Elsevier
Thymoquinone (TQ) a plant-derived dietary of Nigella sativa, is a well-known traditionally
and clinically used natural medicine. The diverse pharmacological properties of TQ have …

[HTML][HTML] Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

YK Mahmoud, HMA Abdelrazek - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Recently, there is growing interest in the natural bioactive components having anticancer
activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa) …

[HTML][HTML] Anticancer activity of thymoquinone against breast cancer cells: Mechanisms of action and delivery approaches

H Shabani, MH Karami, J Kolour, Z Sayyahi… - Biomedicine & …, 2023 - Elsevier
The rising incidence of breast cancer has been a significant source of concern in the
medical community. Regarding the adverse effects and consequences of current treatments …

Thymoquinone‐induced antitumor and apoptosis in human lung adenocarcinoma cells

S Samarghandian, M Azimi‐Nezhad… - Journal of cellular …, 2019 - Wiley Online Library
Background Lung cancer has been associated with the highest cancer‐associated mortality
rate in the world. Chemotherapeutic management of cancer necessitates introducing new …

Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2-and Src‑mediated phosphorylation of EGF …

J Kundu, BY Choi, CH Jeong… - Oncology …, 2014 - spandidos-publications.com
Thymoquinone (TQ), a compound isolated from black seed oil (Nigella sativa), has been
reported to possess anti-inflammatory and anticancer activities. However, the molecular …

[HTML][HTML] The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies

M Butnariu, C Quispe, J Herrera-Bravo, P Helon… - Biomedicine & …, 2022 - Elsevier
Thymoquinone (TQ) is a secondary metabolite found in abundance in very few plant species
including Nigella sativa L., Monarda fistulosa L., Thymus vulgaris L. and Satureja montana …