A systematic review of suggested molecular strata, biomarkers and their tissue sources in ALS

UG Vijayakumar, V Milla, MY Cynthia Stafford… - Frontiers in …, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is an incurable
neurodegenerative condition, characterized by the loss of upper and lower motor neurons. It …

From multi-omics approaches to precision medicine in amyotrophic lateral sclerosis

G Morello, S Salomone, V D'Agata… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disorder,
caused by the degeneration of upper and lower motor neurons for which there is no truly …

Amyotrophic lateral sclerosis: a focus on disease progression

AC Calvo, R Manzano, DMF Mendonça… - BioMed research …, 2014 - Wiley Online Library
Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a
neurodegenerative disease in which motor neuron death is induced, a wide range of …

Imaging neurochemistry and brain structure tracks clinical decline and mechanisms of ALS in patients

OC Andronesi, K Nicholson, K Jafari-Khouzani… - Frontiers in …, 2020 - frontiersin.org
Background: Oxidative stress and protein aggregation are key mechanisms in amyotrophic
lateral sclerosis (ALS) disease. Reduced glutathione (GSH) is the most important …

The heterogeneity of amyotrophic lateral sclerosis: a possible explanation of treatment failure

E Beghi, T Mennini, C Bendotti, P Bigini… - Current medicinal …, 2007 - ingentaconnect.com
Amyotrophic lateral sclerosis (ALS) is a severe clinical condition characterized by upper and
lower motor neuron degeneration for which there is no truly effective treatment. The absence …

Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS

M Otto, R Bowser, M Turner, J Berry… - Amyotrophic Lateral …, 2012 - Taylor & Francis
Despite major advances in deciphering the neuropathological hallmarks of amyotrophic
lateral sclerosis (ALS), validated neurochemical biomarkers for monitoring disease activity …

Biomarkers for amyotrophic lateral sclerosis

R Bowser, M Cudkowicz… - Expert review of …, 2006 - Taylor & Francis
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease. ALS
is a fatal neurodegenerative disease and clinical diagnosis typically takes many months to …

Protein biomarkers for amyotrophic lateral sclerosis

H Ryberg, R Bowser - Expert review of proteomics, 2008 - Taylor & Francis
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with largely
unknown pathogenesis that typically results in death within a few years from diagnosis …

Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells

G Nardo, S Pozzi, M Pignataro, E Lauranzano… - PloS one, 2011 - journals.plos.org
Background Amyotrophic lateral sclerosis (ALS) is a fatal progressive motor neuron disease,
for which there are still no diagnostic/prognostic test and therapy. Specific molecular …

The 'omics' of amyotrophic lateral sclerosis

D Caballero-Hernandez, MG Toscano… - Trends in molecular …, 2016 - cell.com
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease that primarily
affects motor neurons and is accompanied by sustained unregulated immune responses …