Despite an early understanding of amyotrophic lateral sclerosis (ALS) as a disease affecting
the motor system, including motoneurons in the motor cortex, brainstem, and spinal cord …

The past decade has seen a dramatic increase in the discovery of candidate biomarkers for
ALS. These biomarkers typically can either differentiate ALS from control subjects or predict …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease among
adults. With diagnosis reached relatively late into the disease process, extensive motor cell …

Amyotrophic lateral sclerosis (ALS) displays considerable clinical and genetic
heterogeneity. Machine learning approaches have previously been utilised for patient …

Amyotrophic lateral sclerosis (ALS) is a disorder that involves the degeneration of motor
neurons, muscle atrophy, and paralysis. In a few familiar forms of ALS, mutations in the …

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron diseases
(MND) characterized by progressive selective degeneration of motor neurons. Although …

Amyotrophic Lateral Sclerosis (ALS) is a prototypical neurodegenerative disease
characterized by progressive degeneration of motor neurons both in the brain and spinal …

Background While neuroimaging in ALS has gained unprecedented momentum in recent
years, little progress has been made in the development of viable diagnostic, prognostic and …

Abstract Background 5–10% of amyotrophic lateral sclerosis (ALS) patients presented a
positive family history (fALS). More than 30 genes have been identified in association with …

Cortical dysfunction—specifically, the development of hyperexcitability—seems to be an
early and intrinsic feature of sporadic and familial amyotrophic lateral sclerosis (ALS) …