In the earlier work on the oxidation of fatty acids in vitro only fatty acids of short chain length
could be utilized with an appreciable activity xs. The stimulating effect of carnitine on the …

Thus a participation of carnitine in metabolism by forming another type of" activated" acetic
acid was directly demonstrated. On the other hand carnitine had been shown to be a …

Acetylcarnitine added in catalytic amounts to kidney mitochondria produces an active
oxidation of endogenous fatty acids. 2. In conditions of mitochondrialaging', under which …

Recently, we reported that carnitine may be reversibly acetylated by mitochondria from
several tissues of the rat. When acetylcarnitine is deacetylated, a concomitant oxygen …

1. The effect of acylcarnitines and of free carnitine on the oxidation of pyruvate in rat-heart
mitochondria has been investigated. 2. 2. Free carnitine stimulates the decarboxylation of …

Friedman and Fraenkel (3) found that carnitine is acetylated enzymically by soluble extracts
of liver in the presence of acetate, adenosine triphosphate, and coenzyme A. When …

The addition of dl-carnitine to various types of particulate liver preparations resulted in
augmented oxidation of labeled palmitate and stearate. In contrast, carnitine exerted little if …

In animal cells long chain fatty acids are transferred into the mitochondria for oxidation as
acylcarnitines. Carnitine palmitoyltransferase I in the outer membrane, and carnitine …

1. The oxidation of l-caprinylcarnitine, l-palmitylcarnitine and pyruvate has been compared
in rat-liver mitochondria. 2. 2. In the presence of malonate about equal amounts of …

Functional activity of the" external" carnitine palmitoyltransferase in intact mitochondria,
prepared from hearts from various sources, was estimated by measuring respiration by …