Simple Summary Nuclear factor erythroid-derived 2-like 2 (encoded by the Nfe2l2 gene;
NRF2) is a transcription factor that regulates a variety of cytoprotective genes, including …

Abstract The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …

The innate immune system, including phagocytic cells, is the first line of defense against
pathogens. During infection by microorganisms such as viruses, bacteria, or parasites …

The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in
human antioxidant defense response against environmental insults. Small molecular …

The nuclear factor E2-related factor 2 (Nrf2) plays an important role in cellular protection
against cancer, renal, pulmonary, cardiovascular and neurodegenerative diseases where …

The transcription factor Nrf2 (NF-E2-related factor 2) plays a vital role in maintaining cellular
homeostasis, especially upon the exposure of cells to chemical or oxidative stress, through …

The beta zipper (bZip) transcription factor, nuclear factor erythroid 2, like 2 (Nrf2), acting via
an antioxidant/electrophile response element, regulates the expression of several …

Asthma development and pathogenesis are influenced by the interactions of airway
epithelial cells and innate and adaptive immune cells in response to allergens. Oxidative …

The transcription factor NF-E2 p45-related factor 2 (Nrf2; gene name NFE2L2) allows
adaptation and survival under conditions of stress by regulating the gene expression of …

Mechanisms that activate innate antioxidant responses, as a way to mitigate oxidative stress
at the site of action, hold much therapeutic potential in diseases, such as Parkinson's …