[HTML][HTML] Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation

SD Naidu, PR Angelova, EV Knatko, C Leonardi… - Free Radical Biology …, 2023 - Elsevier
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) is the principal
determinant of the cellular redox homeostasis, contributing to mitochondrial function …

[HTML][HTML] Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy

P Basak, P Sadhukhan, P Sarkar, PC Sil - Toxicology reports, 2017 - Elsevier
The Nuclear factor erythroid2-related factor2 (Nrf2), a master regulator of redox
homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant …

The antioxidant transcription factor Nrf2 in cardiac ischemia–reperfusion injury

A Mata, S Cadenas - International journal of molecular sciences, 2021 - mdpi.com
Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that controls cellular
defense responses against toxic and oxidative stress by modulating the expression of genes …

The Nuclear Factor Erythroid 2–Related Factor 2 Activator Oltipraz Attenuates Chronic Hypoxia–Induced Cardiopulmonary Alterations in Mice

S Eba, Y Hoshikawa, T Moriguchi… - American journal of …, 2013 - atsjournals.org
Nuclear factor erythroid 2–related factor 2 (Nrf2) is a key regulator that activates many
antioxidant enzymes. Oxidative stress, which accumulates in diseased lungs associated with …

Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due …

K Yamada, K Asai, F Nagayasu, K Sato, N Ijiri… - BMC pulmonary …, 2016 - Springer
Background Cigarette smoking-induced oxidative stress is known to be a key mechanism in
COPD pathogenesis. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a central …

Roles nrf2 plays in myeloid cells and related disorders

E Kobayashi, T Suzuki… - Oxidative medicine and …, 2013 - Wiley Online Library
The Keap1‐Nrf2 system protects animals from oxidative and electrophilic stresses. Nrf2 is a
transcription factor that induces the expression of genes essential for detoxifying reactive …

Nrf2 amplifies oxidative stress via induction of Klf9

SN Zucker, EE Fink, A Bagati, S Mannava… - Molecular cell, 2014 - cell.com
Reactive oxygen species (ROS) activate NF-E2-related transcription factor 2 (Nrf2), a key
transcriptional regulator driving antioxidant gene expression and protection from oxidant …

Synergistic interaction between heme oxygenase (HO) and nuclear-factor E2-related factor-2 (Nrf2) against oxidative stress in cardiovascular related diseases

J Fomusi Ndisang - Current Pharmaceutical Design, 2017 - ingentaconnect.com
Background: Nuclear factor-erythroid related factor-2 (Nrf2) is a master regulator of
transcriptional activation of anti-oxidants in cells. Similarly, heme oxygenase (HO) is a …

The Keap1–Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases

P Deshmukh, S Unni, G Krishnappa… - Biophysical reviews, 2017 - Springer
The overproduction of reactive oxygen species (ROS) generates oxidative stress in cells.
Oxidative stress results in various pathophysiological conditions, especially cancers and …

Association of Nrf2 with airway pathogenesis: lessons learned from genetic mouse models

HY Cho, SR Kleeberger - Archives of toxicology, 2015 - Springer
Nrf2 is a key transcription factor for antioxidant response element (ARE)-bearing genes
involved in diverse host defense functions including redox balance, cell cycle, immunity …