The serotonin–BDNF duo: Developmental implications for the vulnerability to psychopathology

JR Homberg, R Molteni, F Calabrese… - … & Biobehavioral Reviews, 2014 - Elsevier
Abstract Serotonin (5-HT) and brain-derived neurotrophin factor (BDNF) are known to
modulate behavioral responses to stress and to mediate the therapeutic efficacy of …

Lack of serotonin transporter alters BDNF expression in the rat brain during early postnatal development

F Calabrese, G Guidotti, A Middelman, G Racagni… - Molecular …, 2013 - Springer
It is well established that alterations of the serotoninergic system may contribute to the
pathophysiology of mood disorders. Accordingly, it has been demonstrated that genetic …

Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: insights in depression

ZM Ignácio, GZ Réus, HM Abelaira, J Quevedo - Neuroscience, 2014 - Elsevier
Epidemiological studies have shown significant results in the interaction between the
functions of brain-derived neurotrophic factor (BDNF) and 5-HT in mood disorders, such as …

Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans

R Molteni, A Cattaneo, F Calabrese, F Macchi… - Neurobiology of …, 2010 - Elsevier
In order to identify the molecular mechanisms that may contribute to the enhanced
susceptibility to depression under serotonin transporter (SERT) dysfunction, we analyzed …

Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation

S Migliarini, G Pacini, B Pelosi, G Lunardi… - Molecular …, 2013 - nature.com
Despite increasing evidence suggests that serotonin (5-HT) can influence neurogenesis,
neuronal migration and circuitry formation, the precise role of 5-HT on central nervous …

Neuronal and behavioral plasticity: The role of serotonin and BDNF systems tandem

NK Popova, VS Naumenko - Expert opinion on therapeutic targets, 2019 - Taylor & Francis
ABSTRACT Introduction: Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are
known as principal players in different kinds of plasticity. The 5-HT–BDNF interaction in early …

Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders?

KP Lesch, R Mössner - Biological psychiatry, 1998 - Elsevier
Serotonin (5-HT) is an important regulator of morphogenetic activities during early central
nervous system development, including cell proliferation, migration, and differentiation. The …

Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice

MS Ansorge, E Morelli, JA Gingrich - Journal of Neuroscience, 2008 - Soc Neuroscience
Serotonin (5-HT) acts as a neurotransmitter, but also modulates brain maturation during
early development. The demonstrated influence of genetic variants on brain function …

Interaction between BDNF and serotonin: role in mood disorders

K Martinowich, B Lu - Neuropsychopharmacology, 2008 - nature.com
Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are two
seemingly distinct signaling systems that play regulatory roles in many neuronal functions …

New insights into how serotonin selective reuptake inhibitors shape the developing brain

JA Gingrich, H Malm, MS Ansorge, A Brown… - Birth defects …, 2017 - Wiley Online Library
Development passes through sensitive periods, during which plasticity allows for genetic
and environmental factors to exert indelible influence on the maturation of the organism. In …