Context: Congenital hyperinsulinism (HI) is the most common cause of hypoglycemia in
children. The risk of permanent brain injury in infants with HI continues to be as high as 25 …

Congenital hyperinsulinism (CHI) is a rare disease characterized by an unregulated insulin
release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe …

Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Insulin secretion from pancreatic β-cells is tightly regulated to keep fasting blood glucose
concentrations within the normal range (3.5-5.5 mmol/L). Hyperinsulinaemic hypoglycaemia …

Congenital hyperinsulinism (HI) is an inappropriate insulin secretion by the pancreatic β-
cells secondary to various genetic disorders. The incidence is estimated at 1/50, 000 live …

Congenital hyperinsulinism is a cause of persistent hypoglycaemia in the neonatal period. It
is a heterogeneous disease with respect to clinical presentation, molecular biology, genetic …

Hyperinsulinaemic hypoglycaemia (HH) is characterized by unregulated insulin secretion
from pancreatic β-cells. Untreated hypoglycaemia in infants can lead to seizures …

Congenital hyperinsulinism (HI) is the most frequent cause of persistent hypoglycemia in
infants and children. Delays in diagnosis and initiation of appropriate treatment contribute to …

Congenital hyperinsulinism is characterised by the inappropriate release of insulin during
hypoglycaemia. This potentially life-threatening disorder can occur in isolation, or present as …

Context: Hypoglycemia due to congenital hyperinsulinism (HI) is caused by mutations in 9
genes. Objective: Our objective was to correlate genotype with phenotype in 417 children …