A major problem in the discovery of new biologically active compounds from natural
products is the reisolation of known compounds. Such reisolations waste time and …

In natural-product drug discovery, finding new compounds is the main task, and thus fast
dereplication of known compounds is essential. This is usually performed by manual liquid …

Effective and rapid dereplication is a hallmark of present-day drug discovery from natural
sources. This project strove to both decrease the time and expand the structural diversity …

In drug discovery, reliable and fast dereplication of known compounds is essential for
identification of novel bioactive compounds. Here, we show an integrated approach using …

The use of an HPLC bioactivity profiling/microtiter plate technique in conjunction with
capillary probe NMR instrumentation and access to appropriate databases effectively short …

Having entered the Genomic Era, it is now evident that the biosynthetic potential of
filamentous fungi is much larger than was thought even a decade ago. Fungi harbor many …

The discovery of novel and/or new bioactive natural products from biota sources is often
confounded by the reisolation of known natural products. Dereplication strategies that …

Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …

Recent published sequencing of fungal genomes has revealed that these microorganisms
have a surprisingly large number of secondary metabolite pathways that can serve as …

Many drug discovery projects rely on commercial compounds to discover active leads.
However, current commercial libraries, with mostly synthetic compounds, access a small …