Background Prostate cancer risk stratification using single-nucleotide polymorphisms
(SNPs) demonstrates considerable promise in men of European, Asian, and African genetic …

Background Accurate prostate cancer risk assessment will enable identification of men who
are at increased risk of the disease. Using the UK Biobank population‐based cohort, we …

Purpose: Combined information on single nucleotide polymorphisms and prostate specific
antigen offers opportunities to improve the performance of screening by risk stratification. We …

Context Although the widespread use of prostate-specific antigen (PSA) has led to an early
detection of prostate cancer (PCa) and a reduction of metastatic disease at diagnosis, PSA …

There is substantial heterogeneity in the biology and clinical course of prostate cancer
across patients with this diagnosis. Although prostate cancer is the most common cancer …

BACKGROUND: Recent genome-wide association studies have identified several
independent single nucleotide polymorphisms (SNPs) strongly associated with prostate …

Polygenic risk scores (PRSs) of common genetic variants have shown promise in prostate
cancer risk stratification, but their validity across populations has yet to be confirmed. We …

Objective Prostate cancer is the second most frequent cancer in men worldwide and kills
over 250,000 men worldwide every year. Prostate cancer is a heterogeneous disease at the …

The aim of this study was to investigate if a genetic risk score including 33 common genetic
variants improves prediction of prostate cancer when added to measures of prostate …

Genetic models for cancer have been evaluated using almost exclusively European data,
which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated …