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[HTML][HTML] Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma

JL Marks, S Broderick, Q Zhou, D Chitale, AR Li… - Journal of thoracic …, 2008 - Elsevier
Background Somatic mutations in EGFR (exons 19 and 21) and KRAS (exon 2) are found in
lung adenocarcinomas and have potential prognostic value in patients with advanced …
被引用次数：288 相关文章 所有 9 个版本
[PDF] researchgate.net

Impact of KRAS and EGFR Gene Mutations on Recurrence and Survival in Patients with Surgically Resected Lung Adenocarcinomas

M Sonobe, M Kobayashi, M Ishikawa, R Kikuchi… - Annals of surgical …, 2012 - Springer
Background Oncogenic gene mutations observed in lung adenocarcinomas, such as
epidermal growth factor receptor (EGFR) and KRAS, have some predictive value for …
被引用次数：61 相关文章 所有 9 个版本
[HTML] sciencedirect.com

[HTML][HTML] Distinct clinical course of EGFR-mutant resected lung cancers: results of testing of 1118 surgical specimens and effects of adjuvant gefitinib and erlotinib

SP D'Angelo, YY Janjigian, N Ahye, GJ Riely… - Journal of Thoracic …, 2012 - Elsevier
Background: EGFR and KRAS mutations are mutually exclusive and predict outcomes with
epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment in patients …
被引用次数：205 相关文章 所有 10 个版本
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[HTML][HTML] Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma

T Kosaka, Y Yatabe, R Onozato, H Kuwano… - Journal of Thoracic …, 2009 - Elsevier
Introduction: Although mutation of the epidermal growth factor receptor (EGFR) gene is
predictive for the response to EGFR-tyrosine kinase inhibitor, its prognostic impact for …
被引用次数：285 相关文章 所有 6 个版本

Activating mutations within the EGFR kinase domain: a molecular predictor of disease-free survival in resected pulmonary adenocarcinoma

YJ Lee, IK Park, MS Park, HJ Choi, BC Cho… - Journal of cancer …, 2009 - Springer
Purpose Although epidermal growth factor receptor (EGFR) tyrosine kinase (TK) mutations
are highly predictive of response to EGFR TK inhibitors in advanced non-small-cell lung …
被引用次数：75 相关文章 所有 15 个版本

Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung

YT Kim, T Kim, DS Lee, SJ Park, J Park, SJ Seo… - Lung Cancer, 2008 - Elsevier
Recent studies have reported that clinical response to epidermal growth factor receptor
(EGFR) inhibitors is associated with somatic changes of EGFR in the advanced stage of lung …
被引用次数：109 相关文章 所有 10 个版本
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[HTML][HTML] Prognostic value of epidermal growth factor receptor gene mutation in resected lung adenocarcinoma

C Deng, Y Zhang, Z Ma, F Fu, L Deng, Y Li… - The Journal of thoracic …, 2021 - Elsevier
Background Mutation of the EGFR gene is known as a predictor for the response to EGFR
tyrosine kinase inhibitor. Although EGFR mutation status is proposed to be incorporated in …
被引用次数：42 相关文章 所有 4 个版本
[PDF] wiley.comFull View

Association of KRAS and EGFR mutations with survival in patients with advanced lung adenocarcinomas

ML Johnson, CS Sima, J Chaft, PK Paik, W Pao… - Cancer, 2013 - Wiley Online Library
BACKGROUND: Lung adenocarcinomas can be distinguished by identifying mutated driver
oncogenes, including epidermal growth factor receptor (EGFR) and KRAS. Mutations in …
被引用次数：171 相关文章 所有 8 个版本
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[HTML][HTML] Prognostic impacts of EGFR mutation status and subtype in patients with surgically resected lung adenocarcinoma

K Takamochi, S Oh, T Matsunaga, K Suzuki - The Journal of thoracic and …, 2017 - Elsevier
Objective Epidermal growth factor receptor (EGFR) gene mutation status is a well-
established predictor of the efficacy of EGFR tyrosine-kinase inhibitor (TKI) therapy in …
被引用次数：68 相关文章 所有 5 个版本
[HTML] nih.gov

KRAS mutation is a significant prognostic factor in early-stage lung adenocarcinoma

K Kadota, CS Sima, ME Arcila, C Hedvat… - The American journal …, 2016 - journals.lww.com
The potential clinical impact of KRAS and epidermal growth factor receptor (EGFR)
mutations has been investigated in lung adenocarcinomas; however, their prognostic value …
被引用次数：57 相关文章 所有 7 个版本