Correlation of CYP2B6-516G> T polymorphism with plasma efavirenz concentration and depression in HIV-infected adults in Northern Thailand
L Aurpibul, N Chotirosniramit… - Current HIV …, 2012 - ingentaconnect.com
Background: Single nucleotide polymorphism of the hepatic cytochrome P450 isoenzyme
2B6 (CYP2B6) gene is a cause of variation in plasma efavirenz (EFV) concentrations. We …
2B6 (CYP2B6) gene is a cause of variation in plasma efavirenz (EFV) concentrations. We …
High plasma efavirenz concentration and CYP2B6 polymorphisms in Thai HIV-1 infections
C Sukasem, M Chamnanphon, N Koomdee… - Drug metabolism and …, 2013 - Elsevier
Efavirenz is mainly metabolized by cytochrome P450 2B6 (CYP2B6). This study aimed to
examine the frequencies of CYP2B6 and the association between CYP2B6 polymorphisms …
examine the frequencies of CYP2B6 and the association between CYP2B6 polymorphisms …
Pharmacogenetic markers of CYP2B6 associated with efavirenz plasma concentrations in HIV‐1 infected Thai adults
C Sukasem, TR Cressey, P Prapaithong… - British journal of …, 2012 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Interindividual variability in efavirenz
plasma concentrations is associated with CYP2B6 genetic polymorphisms.• Twenty‐nine …
plasma concentrations is associated with CYP2B6 genetic polymorphisms.• Twenty‐nine …
Low level of efavirenz in HIV-1-infected Thai adults is associated with the CYP2B6 polymorphism
C Sukasem, W Manosuthi, N Koomdee, S Santon… - Infection, 2014 - Springer
Background Human immunodeficiency virus type 1 (HIV-1) infections with a plasma
efavirenz concentration of< 1,000 ng/mL appear to have a high risk for the emergence of …
efavirenz concentration of< 1,000 ng/mL appear to have a high risk for the emergence of …
Effect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection
X Meng, K Yin, J Wang, P Dong, L Liu, Y Shen, L Shen… - PloS one, 2015 - journals.plos.org
Objectives The main aim of this study was to investigate the effect of CYP2B6 gene
polymorphisms on efavirenz (EFV) plasma concentrations in Han Chinese patients with …
polymorphisms on efavirenz (EFV) plasma concentrations in Han Chinese patients with …
Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected …
V Gounden, C Van Niekerk, T Snyman… - AIDS research and …, 2010 - Springer
Abstract Background The 516G> T polymorphism in exon 4 of the CYP2B6 gene has been
associated with increased plasma Efavirenz (EFV) concentrations. EFV concentrations …
associated with increased plasma Efavirenz (EFV) concentrations. EFV concentrations …
CYP2B6 (c.516G→T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV‐infected patients
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Cytochrome P450 (CYP) 2B6
polymorphisms, particularly c. 516G→ T, are strongly associated with plasma efavirenz …
polymorphisms, particularly c. 516G→ T, are strongly associated with plasma efavirenz …
Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults
S Uttayamakul, S Likanonsakul, W Manosuthi… - AIDS research and …, 2010 - Springer
Abstract Background Cytochrome P450 2B6 (CYP2B6) metabolizes efavirenz and
nevirapine, the major core antiretroviral drugs for HIV in Thailand. Rifampicin, a critical …
nevirapine, the major core antiretroviral drugs for HIV in Thailand. Rifampicin, a critical …
Large variability in plasma efavirenz concentration in Papua New Guinea HIV/AIDS patients associated with high frequency of CYP2B6 516T allele
N Bordin Andriguetti, HK Van Schalkwyk… - Clinical and …, 2021 - Wiley Online Library
Abstract Papua New Guinea (PNG) has a high HIV/AIDS prevalence and very high
frequency of the CYP2B6 c. 516G> T (rs3745274) variant. We have conducted the first …
frequency of the CYP2B6 c. 516G> T (rs3745274) variant. We have conducted the first …
CYP2B6 G516T Polymorphism but Not Rifampin Coadministration Influences Steady-State Pharmacokinetics of Efavirenz in Human Immunodeficiency Virus-Infected …
G Ramachandran, AK Hemanth Kumar… - Antimicrobial agents …, 2009 - Am Soc Microbiol
The dose of efavirenz during concomitant rifampin (RMP) administration is a matter of
debate. We studied the influence of RMP coadministration on the steady-state …
debate. We studied the influence of RMP coadministration on the steady-state …