Botulinum neurotoxin serotype A (BoNT/A) has achieved a dichotomous status in modern
medicine; it is both a versatile treatment for several neurological disorders and a lethal …

Botulinum neurotoxin (BoNT), the causative agent of botulism, is acknowledged to be the
most poisonous protein known. BoNT proteases disable synaptic vesicle exocytosis by …

Despite its extreme toxicity, botulinum neurotoxin is widely utilized in low doses as a
treatment for several neurological disorders; higher doses cause the neuroparalytic …

The seven antigenically distinct serotypes of Clostridium botulinum neurotoxins, the
causative agents of botulism, block the neurotransmitter release by specifically cleaving one …

Botulinum neurotoxins (BoNTs) are zinc proteases that cleave SNARE proteins to elicit
flaccid paralysis by inhibiting neurotransmitter-carrying vesicle fusion to the plasma …

Clostridial neurotoxins are the causative agents of the neuroparalytic disease botulism and
tetanus. They block neurotransmitter release through specific proteolysis of one of the three …

Botulinum neurotoxins are metalloproteases that specifically cleave N-ethylmaleimide-
sensitive factor attachment protein receptor (SNARE) proteins in synaptic terminals, resulting …

Botulinum neurotoxins (BoNTs) are metalloproteases which block neuroexocytosis via
specific cleavage and inactivation of SNARE proteins. Such proteolysis accounts for the …

Botulinum neurotoxins (BoNTs) cause flaccid paralysis by inhibiting neurotransmission at
cholinergic nerve terminals. Each BoNT consists of three domains that are essential for …

The high toxicity of the seven serotypes of botulinum neurotoxins (BoNT/A to G), together
with their specificity and reversibility, includes them in the list A of potential bioterrorism …