Regulator of G protein signaling contributes to the development and aflatoxin biosynthesis in Aspergillus flavus through the regulation of Gα activity

R Xie, K Yang, E Tumukunde, Z Guo… - Applied and …, 2022 - Am Soc Microbiol
Heterotrimeric G-proteins play crucial roles in growth, asexual development, and
pathogenicity of fungi. The regulator of G-protein signaling (RGS) proteins function as …

G Protein α Subunit GpaB is Required for Asexual Development, Aflatoxin Biosynthesis and Pathogenicity by Regulating cAMP Signaling in Aspergillus flavus

Y Liu, K Yang, Q Qin, G Lin, T Hu, Z Xu, S Wang - Toxins, 2018 - mdpi.com
The heterotrimeric G proteins are critical for signal transduction and function in numerous
biological processes including vegetative growth, asexual development and fungal …

RgsA Attenuates the PKA Signaling, Stress Response, and Virulence in the Human Opportunistic Pathogen Aspergillus fumigatus

HP Lwin, YH Choi, MW Lee, JH Yu… - International Journal of …, 2019 - mdpi.com
The regulator of G-protein signaling (RGS) proteins play an important role in upstream
control of heterotrimeric G-protein signaling pathways. In the genome of the human …

RgsD negatively controls development, toxigenesis, stress response, and virulence in Aspergillus fumigatus

Y Kim, MW Lee, SC Jun, YH Choi, JH Yu, KS Shin - Scientific Reports, 2019 - nature.com
The regulator of G protein signaling (RGS) domain proteins generally attenuate
heterotrimeric G protein signaling, thereby fine-tune the duration and strength of signal …

Comparative Characterization of G Protein α Subunits in Aspergillus fumigatus

YH Choi, NY Lee, SS Kim, HS Park, KS Shin - Pathogens, 2020 - mdpi.com
Trimeric G proteins play a central role in the G protein signaling in filamentous fungi and Gα
subunits are the major component of trimeric G proteins. In this study, we characterize three …

Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans

Y Jae-Hyuk - Journal of Microbiology, 2006 - koreascience.kr
Heterotrimeric G proteins (G proteins) are conserved in all eukaryotes and are crucial
components sensing and relaying external cues into the cells to elicit appropriate …

Characterizations and functions of regulator of G protein signaling (RGS) in fungi

Y Wang, Z Geng, D Jiang, F Long, Y Zhao, H Su… - Applied microbiology …, 2013 - Springer
Proteins that serve as regulator of G protein signaling (RGS) primarily function as GTPase
accelerators that promote GTP hydrolysis by the Gα subunits, thereby inactivating the G …

Functional analyses of regulators of G protein signaling in Gibberella zeae

AR Park, AR Cho, JA Seo, K Min, H Son, J Lee… - Fungal genetics and …, 2012 - Elsevier
Regulators of G protein signaling (RGS) proteins make up a highly diverse and
multifunctional protein family that plays a critical role in controlling heterotrimeric G protein …

Ras subfamily GTPases regulate development, aflatoxin biosynthesis and pathogenicity in the fungus Aspergillus flavus

Z Zhu, G Ma, M Yang, C Tan, G Yang… - Environmental …, 2021 - Wiley Online Library
Ras subfamily proteins are molecular switches in signal transduction pathways of many
eukaryotes that regulate a variety of cellular processes. Here, the Ras subfamily, encoded …

Characteristics of a Regulator of G-Protein Signaling (RGS) rgsC in Aspergillus fumigatus

Y Kim, IB Heo, JH Yu, KS Shin - Frontiers in microbiology, 2017 - frontiersin.org
The regulator of G-protein signaling (RGS) proteins have a conserved RGS domain that
facilitates the intrinsic GTPase activity of an activated Gα subunit of heterotrimeric G protein …