Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector
function | Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …

Obesity is a major cancer risk factor, but how differences in systemic metabolism change the
tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we …

Obesity is a risk factor for cancer incidence and cancer mortality. The association of obesity
and cancer is attributed to multiple factors, but the tightest linkage is with the chronic, low …

Obesity is a mounting health concern in the United States and is associated with an
increased risk for developing several cancers, including renal cell carcinoma (RCC) …

Obesity increases the risk of cancer. Increased levels of hormones (such as oestrogen,
insulin, insulin-like growth factor, and leptin), free fatty acid-induced production of reactive …

Highlights•Obesity leads to a state of metabolic and immune dysfunction.•T cells are highly
tuned by multiple intrinsic and extrinsic metabolic mechanisms.•Obesity can alter the efficacy …

Nearly 70% of adults in the US are currently overweight or obese. Despite such high
prevalence, the impact of obesity on antitumor immunity and immunotherapy outcomes …

Although cancer immunotherapy has achieved significant breakthroughs in recent years, its
overall efficacy remains limited in the majority of patients. One major barrier is exhaustion of …

How tumor-infiltrating T lymphocytes (TILs) adapt to the metabolic constrains within the
tumor microenvironment (TME) and to what degree this affects their ability to combat tumor …

Cancer is one of the leading causes of morbidity and mortality worldwide. Traditional
treatments include surgery, chemotherapy and radiation therapy, and more recently targeted …