For mitochondria‐targeting delivery, a coupling reaction between poly (ε‐caprolactone) diol
(PCL diol) and 4‐carboxybutyltriphenylphosphonium (4‐carboxybutyl TPP) results in the …

Bioactivable nanocarrier systems have favorable characteristics such as high cellular
uptake, target specificity, and an efficient intracellular release mechanism. In this study, we …

The importance of mitochondrial delivery of an anticancer drug to cancer cells has been
recognized to improve therapeutic efficacy. The introduction of lipophilic cations, such as …

Mitochondrial-targeting therapy is considered an important strategy for cancer treatment.(3-
Carboxypropyl) triphenyl phosphonium (CTPP) is one of the candidate molecules that can …

Mitochondrial-oriented delivery of anticancer drugs has been considered as a promising
strategy to improve the antitumor efficiency of chemotherapeutics. However, the …

Although having undergone decades of development, nanoparticulate drug delivery
vehicles for efficient cancer therapy remain a challenge, confined by low drug loading …

Mitochondrial dysfunctions cause numerous human disorders. A platform technology based
on biodegradable polymers for carrying bioactive molecules to the mitochondrial matrix …

Targeting delivery of anticancer drugs that can interact with DNA into mitochondria of cancer
cells has been demonstrated to be an effective method to combat drug resistance. In this …

Aim: The objective of this study was to develop a mitochondria-targeted anticancer drug,
docetaxel (DTX), for chemotherapy. Materials & methods: The DTX was conjugated to 4 …

Mitochondria are important targets for the intracellular delivery of drugs and DNA. For
mitochondria-targeted delivery, a mitochondriotropic molecule, triphenylphosphonium …