To the Editor: Tumor necrosis factor (TNF) is recognized as an important cytokine in the
pathogenesis of Crohn_s disease (CD), and TNF blockade has been effective in the …

To the Editor: Antagonizing tumor necrosis factor alpha (TNF-a) has shown to be an effective
treatment strategy in patients with Crohn's disease (CD) and ulcerative colitis (UC) …

To the Editor: We report on a young female smoker who developed severe bilateral
pneumococcal pneumonia after infliximab therapy for Crohn's disease. She suffered from …

Discussion This is the second case report of the use of maintenance adalimumab during
pregnancy and the first reported use of adalimumab to treat Crohn's disease involving an …

To the Editor: In our experience, local injection of infliximab, after surgical drainage of the
sepsis for treatment of complex perianal Crohn's disease, is effective and associated with a …

To the Editor: The probable association of anti–tumor necrosis factor α (TNF-α) monoclonal
antibody therapy with malignant conditions has been recently reported in two patients with …

2274 Letters to the Editor AJG–Vol. 96, No. 7, 2001 infusion was not given. The patient had
received her second infliximab infusion 4 wk prior and her first infusion 6 wk prior. The …

To the Editor: With great interest we read the recent review in Inflammatory Bowel Diseases
by Long et al1 on nonmelanoma skin cancer (NMSC) in inflammatory bowel disease (IBD) …

What is known and objectives The safety of continued ustekinumab (UST) therapy during
pregnancy remains unclear in patients with Crohn's disease (CD). There are no meta …

To the Editor: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis associated with
systemic diseases such as rheumatoid arthritis or inflammatory bowel disease (IBD) in up to …