The pathogenic role for B cells in the context of relapsing remitting multiple sclerosis (MS) is
incompletely defined. Although classically considered a T cell-mediated disease, B cell …

Important antibody-independent pathogenic roles of B cells are emerging in autoimmune
diseases, including multiple sclerosis (MS). The contrasting results of different treatments …

Multiple sclerosis (MS) is a severe disease of the central nervous system (CNS)
characterized by autoimmune inflammation and neurodegeneration. Historically, damage to …

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Once thought to be primarily driven by T cells, B cells are emerging as central …

Autoimmune B cells play a major role in mediating tissue damage in multiple sclerosis (MS).
In MS, B cells are believed to cross the blood-brain barrier and undergo stimulation, antigen …

Increasing evidence has suggested that both antibody-dependent and antibody-
independent functions of B cells are involved in multiple sclerosis (MS). The contrasting …

The success of ocrelizumab in reducing confirmed disability accumulation in primary
progressive multiple sclerosis (PPMS) via CD20-targeted depletion implicates B cells as …

In multiple sclerosis (MS), lymphocyte—in particular B cell—transit between the central
nervous system (CNS) and periphery may contribute to the maintenance of active disease …

Although many suspected autoimmune diseases are thought to be T cell-mediated, the
response to therapy indicates that depletion of B cells consistently inhibits disease activity. In …

There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …