T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy
that results from the transformation of immature T-cell progenitors. Aberrant cell growth and …

Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly
associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor resulting
from the malignant transformation of immature T-cell progenitors. Originally associated with …

Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very
common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses …

The identification of activating mutations in NOTCH1 in the majority of T-cell acute
lymphoblastic leukemias and lymphomas (T-ALL) has brought much interest in inhibiting …

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy of
thymocytes affecting preferentially children and adolescents. The disease is heterogeneous …

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is characterized by aberrant
activation of NOTCH1 in over 60% of T-ALL cases. The high prevalence of activating …

Activating mutations of NOTCH1 (a well-known oncogene in T-cell acute lymphoblastic
leukemia) are present in∼ 4–13% of chronic lymphocytic leukemia (CLL) cases, where they …

Gain-of-function NOTCH1 mutations are found in 50%–70% of human T cell acute
lymphoblastic leukemia/lymphoma (T-ALL) cases. Gain-of-function NOTCH1 alleles that …

Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal
translocations that involve NOTCH1, a gene encoding a transmembrane receptor that …