[HTML][HTML] New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking …
The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed
in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs …
in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs …
[HTML][HTML] Synthesis, molecular docking and ADMET studies of bis-benzimidazole-based thiadiazole derivatives as potent inhibitors, in vitro α-amylase and α …
Different research synthetic methods have been developed recently for the synthesis of bis-
benzimidazole analogs to investigate various biological significances. In this present study …
benzimidazole analogs to investigate various biological significances. In this present study …
Synthesis, characterization, α-glucosidase inhibition and molecular modeling studies of some pyrazoline-1H-1, 2, 3-triazole hybrids
A series of molecular hybrids based on pyrazoline and 1, 2, 3-triazole pharmacophores
were designed and synthesized as antidiabetic agents. The structures of all the derivatives …
were designed and synthesized as antidiabetic agents. The structures of all the derivatives …
Computer-aided modeling of triazole analogues, docking studies of the compounds on DNA gyrase enzyme and design of new hypothetical compounds with efficient …
SE Adeniji, DE Arthur, M Abdullahi… - Journal of …, 2022 - Taylor & Francis
The increasing problem of multi-drug resistant-tuberculosis has focused attention on
developing new drugs that are not only active against drug-resistant tuberculosis, but also …
developing new drugs that are not only active against drug-resistant tuberculosis, but also …
[HTML][HTML] 2D QSAR, design, docking study and ADMET of some N-aryl derivatives concerning inhibitory activity against Alzheimer disease
Background Alzheimer disease (AD) is an ailment that disturbs mainly people of old age.
The fundamental remedial way to deal with AD depends on the utilization of AChEI. The …
The fundamental remedial way to deal with AD depends on the utilization of AChEI. The …
Synthesis, molecular docking study of thiazole derivatives and exploring their dual inhibitor potentials against α-amylase and α-glucosidase
Diabetes mellitus is one of the most chronic metabolic diseases. The current study
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
Novel α-amylase and α-glucosidase inhibitors from selected Nigerian antidiabetic plants: an in silico approach
This study aimed to identify novel α-amylase and α-glucosidase inhibitors from Nigerian
antidiabetic plants through in silico approach. Virtual screening of the 93 phytoconstituents …
antidiabetic plants through in silico approach. Virtual screening of the 93 phytoconstituents …
[HTML][HTML] Exploring the therapeutic potential of benzothiazine-pyrazole hybrid molecules against alpha-glucosidase: Pharmacological and molecular modelling based …
S Taj, M Ahmad, A Alshammari, A Alghamdi… - Saudi Journal of …, 2022 - Elsevier
Diabetes mellitus (DM) is a metabolic disorder and a significant health problem all over the
world. The current study elucidates the inhibitory potentials of the benzothiazine-pyrazole …
world. The current study elucidates the inhibitory potentials of the benzothiazine-pyrazole …
[HTML][HTML] Quantum modelling and molecular docking evaluation of some selected quinoline derivatives as anti-tubercular agents
Mycobacterium tuberculosis has instigated a serious challenge toward the effective
treatment of tuberculosis. The reoccurrence of the resistant strains of the disease to …
treatment of tuberculosis. The reoccurrence of the resistant strains of the disease to …
Development of dual inhibitors against Alzheimer's disease using fragment‐based QSAR and molecular docking
Alzheimer's (AD) is the leading cause of dementia among elderly people. Considering the
complex heterogeneous etiology of AD, there is an urgent need to develop multitargeted …
complex heterogeneous etiology of AD, there is an urgent need to develop multitargeted …