Autophagy has been associated with a variety of diseases especially aging. Human dermal
fibroblasts (HDFs) can internalize and then degrade elastin, collagen and advanced …

Background Autophagy is known as an intracellular cleanup system necessary to maintain
homeostasis of the skin. Many studies have pointed out the relationship between aging and …

Photoaging is characterized by a chronic inflammatory response to UV light. One of the most
prominent features of cutaneous photoaging is wrinkling, which is due primarily to a loss of …

Recently, using 2D-DIGE proteomics we have identified cathepsin B as a novel target of
UVA in human Hs27 skin fibroblasts. In response to chronic exposure to noncytotoxic doses …

Autophagy is an intracellular stress response that is enhanced under starvation conditions,
and also when the cellular components are damaged. Aging accompanies an increase in …

Autophagy is a membrane traffic system that provides sustainable degradation of cellular
components for homeostasis, and is thus considered to promote health and longevity …

Autophagy is an intracellular degradative system that is believed to be involved in the aging
process. The contribution of autophagy to age-related changes in the human skin is unclear …

In the current study, we have extended previous findings aiming at a better understanding of
molecular mechanisms underlying UVB-induced senescence of diploid human dermal …

Autophagy is an essential cellular process that maintains balanced cell life. Restriction in
autophagy may induce degenerative changes in humans. Natural or pathological aging of …

Human skin acts as a barrier to protect our bodies from UV rays and external pathogens and
to prevent water loss. Phenotypes of aging, or natural aging due to chronic damage, include …