Cyclin E1 is essential for the reentry of quiescent cells into the cell cycle. When hypomorphic
mutant Myb mice (MybPlt4) were examined, it was noted that Cyclin E1 (Ccne1) expression …

Colorectal cancer (CRC) is one of the most lethal and common malignancies in the world.
Chemotherapy has been the conventional treatment for metastatic CRC (mCRC) patients …

The MYC oncoprotein and transcription factor is dysregulated in a majority of human
cancers and is considered a major driver of the malignant phenotype. As such, developing …

The evolutionarily conserved Wnt signaling pathway plays essential roles during embryonic
development and tissue homeostasis. Notably, comprehensive genetic studies in …

Due to the lack of effective treatments, advanced colorectal cancer (CRC) remains a leading
cause of cancer death in the United States. Emerging evidence supports the observation …

The prevalence of obesity continues to increase to the extent that it became a worldwide
pandemic. An accumulating body of evidence has associated obesity with the development …

Colorectal cancer (CRC) persists as one of the most prevalent and deadly tumor types in
both men and women worldwide. This is in spite of widespread, effective measures of …

MYC overexpression has been implicated in the pathogenesis of most types of human
cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene …

The myeloid differentiation factor 88 (MyD88), an adaptor protein in regulation of the innate
immunity, functions to regulate immune responses against viral and bacterial infections in …

Cancer cells generate large amounts of lactate derived from glucose regardless of the
available oxygen level. Cancer cells finely control ATP synthesis by modulating the uptake …