Regulation of heme oxygenase-1 expression and MAPK pathways in response to kaempferol and rhamnocitrin in PC12 cells

JT Hong, JH Yen, L Wang, YH Lo, ZT Chen… - Toxicology and applied …, 2009 - Elsevier
Oxidative stress has been considered as a major cause of cellular injuries in a variety of
clinical abnormalities, especially neural diseases. Our aim of research is to investigate the …

Heme oxygenase-1 induction by methylene blue protects RAW264. 7 cells from hydrogen peroxide-induced injury

X Zhang, X Sun, C Wu, J Chen, J Yuan, Q Pang… - Biochemical …, 2018 - Elsevier
Although methylene blue (MB) has showed strong antioxidant effect, its effect related with
heme oxygenase-1 (HO-1) is still unclear. Thus, we investigated the effects of MB on HO-1 …

Apigenin decreases hemin-mediated heme oxygenase-1 induction

A Abate, G Yang, RJ Wong, H Schroder… - Free Radical Biology …, 2005 - Elsevier
Hemin is a strong inducer of heme oxygenase-1 (HO-1) expression in vitro and in vivo.
Whereas moderate overexpression of HO-1 is protective against oxidative stress …

Cytoprotective effects of heme oxygenase-1 induction by 3-O-caffeoyl-1-methylquinic acid

MH Kweon, MJ Jung, HC Sung - Free Radical Biology and Medicine, 2004 - Elsevier
The novel antioxidant 3-O-caffeoyl-one-methylquinic acid (MCGA3) is a methyl chlorogenic
acid derivative isolated from bamboo leaves. MCGA3 scavenges reactive oxygen species …

Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2

S Naidu, V Vijayan, S Santoso, T Kietzmann… - The Journal of …, 2009 - journals.aai.org
Abstract Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting
enzyme of heme degradation. The HO products carbon monoxide and bilirubin not only …

Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways

CC Wu, MC Hsu, CW Hsieh, JB Lin, PH Lai, BS Wung - Life sciences, 2006 - Elsevier
Heme oxygenase-1 (HO-1) is a cytoprotective enzyme activated by various phytochemicals
and we examined the ability of Epigallocatechin-3-gallate (EGCG), the major constituent of …

Induction of heme oxygenase-1 by chamomile protects murine macrophages against oxidative stress

N Bhaskaran, S Shukla, R Kanwal, JK Srivastava… - Life sciences, 2012 - Elsevier
AIMS: Protection of cells from oxidative insult may be possible through direct scavenging of
reactive oxygen species, or through stimulation of intracellular antioxidant defense …

Heme oxygenase‐1, a key enzyme for the cytoprotective actions of halophenols by upregulating Nrf2 expression via activating Erk1/2 and PI3K/Akt in EA. hy926 cells

XE Feng, TG Liang, J Gao, DP Kong… - … medicine and cellular …, 2017 - Wiley Online Library
Increasing evidence has demonstrated that heme oxygenase‐1 (HO‐1) is a key enzyme
triggered by cellular stress, exhibiting cytoprotective, antioxidant, and anti‐inflammatory …

Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt

KC Kim, KA Kang, R Zhang, MJ Piao, GY Kim… - The international journal …, 2010 - Elsevier
The aim of the present study was to examine the cytoprotective effect of eckol, a
phlorotannin found in Ecklonia cava and to elucidate underlying mechanisms. Heme …

Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation

KA Kang, KH Lee, S Chae, R Zhang… - Journal of cellular …, 2006 - Wiley Online Library
We investigated the cytoprotective effect of phloroglucinol, which was isolated from Ecklonia
cava (brown alga), against oxidative stress induced cell damage in Chinese hamster lung …