Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics
DJ Selkoe, D Schenk - Annual review of pharmacology and …, 2003 - annualreviews.org
Degenerative diseases of the brain were long considered among the most obscure and
intractable of human maladies. However, recent advances in understanding their …
intractable of human maladies. However, recent advances in understanding their …
Alzheimer's disease mechanisms and emerging roads to novel therapeutics
C Sala Frigerio, B De Strooper - Annual review of neuroscience, 2016 - annualreviews.org
Ten years of remarkable progress in understanding the fundamental biochemistry of
Alzheimer's disease have been followed by ten years of remarkable and increasing clinical …
Alzheimer's disease have been followed by ten years of remarkable and increasing clinical …
Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Aβ amyloid pathway
CL Masters, K Beyreuther - Brain, 2006 - academic.oup.com
It is now 100 years since the nosological definition of Alzheimer's disease emerged. In the
first 80 years, very little progress was made in understanding the mechanisms that caused …
first 80 years, very little progress was made in understanding the mechanisms that caused …
Current therapeutic options for Alzheimer's disease
A Lleó - Current genomics, 2007 - ingentaconnect.com
Alzheimer's disease (AD) is the most common neurodegenerative disease in the developed
world. The increasing life expectancy in the last years has led to an increase in the …
world. The increasing life expectancy in the last years has led to an increase in the …
[HTML][HTML] Alzheimer mechanisms and therapeutic strategies
There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …
research advances over the past three decades could change this gloomy picture. Genetic …
Therapeutic approaches to Alzheimer's disease
ED Thorsett, LH Latimer - Current opinion in chemical biology, 2000 - Elsevier
Several recent advances have provided new insights and possibilities in defining
therapeutic targets for Alzheimer's disease. Of particular importance is the identification of …
therapeutic targets for Alzheimer's disease. Of particular importance is the identification of …
Disease-modifying approach to the treatment of Alzheimer's disease: From α-Secretase activators to γ-secretase inhibitors and modulators
F Panza, V Solfrizzi, V Frisardi, C Capurso, A D'Introno… - Drugs & aging, 2009 - Springer
In the last decade, advances in understanding the neurobiology of Alzheimer's disease (AD)
have translated into an increase in clinical trials assessing various potential AD treatments …
have translated into an increase in clinical trials assessing various potential AD treatments …
Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles
The bulk of AD research during the last 25 years has been Aβ-centric based on a strong faith
in the Amyloid Cascade Hypothesis which is not supported by the data on humans. To date …
in the Amyloid Cascade Hypothesis which is not supported by the data on humans. To date …
A systemic view of Alzheimer disease—insights from amyloid-β metabolism beyond the brain
J Wang, BJ Gu, CL Masters, YJ Wang - Nature reviews neurology, 2017 - nature.com
Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …
existing treatments for AD produce only a modest amelioration of symptoms. Research into …
Pathophysiological aspects and therapeutic armamentarium of Alzheimer's disease: recent trends and future development
BP Dave, YB Shah, KG Maheshwari… - Cellular and Molecular …, 2023 - Springer
Alzheimer's disease (AD) is the primary cause of dementia and is characterized by the death
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …
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