The search for clinically useful biomarkers of complex disease: a data analysis perspective
EC Considine - Metabolites, 2019 - mdpi.com
Unmet clinical diagnostic needs exist for many complex diseases, which it is hoped will be
solved by the discovery of metabolomics biomarkers. However, as yet, no diagnostic tests …
solved by the discovery of metabolomics biomarkers. However, as yet, no diagnostic tests …
Metabolomics in clinical practice: improving diagnosis and informing management
JD Odom, VR Sutton - Clinical chemistry, 2021 - academic.oup.com
Background Metabolomics is the study of small molecules to simultaneously identify multiple
low molecular weight molecules in a system. Broadly speaking, metabolomics can be …
low molecular weight molecules in a system. Broadly speaking, metabolomics can be …
Translational biomarker discovery in clinical metabolomics: an introductory tutorial
Metabolomics is increasingly being applied towards the identification of biomarkers for
disease diagnosis, prognosis and risk prediction. Unfortunately among the many published …
disease diagnosis, prognosis and risk prediction. Unfortunately among the many published …
Metabolomics: A scoping review of its role as a tool for disease biomarker discovery in selected non-communicable diseases
Metabolomics is a branch of 'omics' sciences that utilises a couple of analytical tools for the
identification of small molecules (metabolites) in a given sample. The overarching goal of …
identification of small molecules (metabolites) in a given sample. The overarching goal of …
From differentiating metabolites to biomarkers
A Koulman, GA Lane, SJ Harrison… - Analytical and bioanalytical …, 2009 - Springer
The current developments in metabolomics and metabolic profiling technologies have led to
the discovery of several new metabolic biomarkers. Finding metabolites present in …
the discovery of several new metabolic biomarkers. Finding metabolites present in …
A framework for development of useful metabolomic biomarkers and their effective knowledge translation
CR Marchand, F Farshidfar, J Rattner, OF Bathe - Metabolites, 2018 - mdpi.com
Despite the significant advantages of metabolomic biomarkers, no diagnostic tests based on
metabolomics have been introduced to clinical use. There are many reasons for this …
metabolomics have been introduced to clinical use. There are many reasons for this …
Metabolomics analysis for biomarker discovery: advances and challenges
MS Monteiro, M Carvalho, ML Bastos… - Current medicinal …, 2013 - ingentaconnect.com
Over the last decades there has been a change in biomedical research with the search for
single genes, transcripts, proteins, or metabolites being substituted by the coverage of the …
single genes, transcripts, proteins, or metabolites being substituted by the coverage of the …
Metabolomics for biomarker discovery: moving to the clinic
A Zhang, H Sun, G Yan, P Wang… - Biomed research …, 2015 - Wiley Online Library
To improve the clinical course of diseases, more accurate diagnostic and assessment
methods are required as early as possible. In order to achieve this, metabolomics offers new …
methods are required as early as possible. In order to achieve this, metabolomics offers new …
Metabolomics in the clinic: A review of the shared and unique features of untargeted metabolomics for clinical research and clinical testing
AD Kennedy, BM Wittmann, AM Evans… - Journal of Mass …, 2018 - Wiley Online Library
Metabolomics is the untargeted measurement of the metabolome, which is composed of the
complement of small molecules detected in a biological sample. As such, metabolomic …
complement of small molecules detected in a biological sample. As such, metabolomic …
How far are we from reliable metabolomics-based biomarkers? The often-overlooked importance of addressing inter-individual variability factors
Á González-Domínguez… - Biochimica et Biophysica …, 2023 - Elsevier
Metabolomics has proven great potential to unravel the molecular basis of diseases.
However, most attempts aimed at identifying reliable metabolomics-based biomarkers for …
However, most attempts aimed at identifying reliable metabolomics-based biomarkers for …