Background Adult hematopoietic stem cells (HSCs) are maintained in a microenvironment,
known as niche in the endosteal regions of the bone marrow. This stem cell niche with low …

Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent
differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone …

Bone marrow transplantation is the primary therapy for numerous hematopoietic disorders.
The efficiency of bone marrow transplantation depends on the function of long-term …

Although hematopoietic stem cells (HSCs) reside in hypoxic niches, the significance of
hypoxia signaling in HSCs remains unclear. In this issue of Cell Stem Cell, Takubo et …

Significance: The effect of redox signaling on hematopoietic stem cell (HSC) function is not
clearly understood. Recent Advances: A growing body of evidence suggests that adult HSCs …

Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic
system and in the regulation of HSC fate, little is currently known about the specific …

Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on
anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy …

Background Hypoxia-inducible factors (HIF) 1 and 2 are transcription factors that regulate
the homeostatic response to low oxygen conditions. Since data related to the importance of …

The enormous regenerative capacity of the blood system to sustain functionally mature cells
are generated from highly proliferative, short‐lived progenitors, which in turn arise from a …

Adult hematopoiesis depends on rare multipotent hematopoietic stem cells (HSCs) that self-
renew and give rise to progenitor cells, which differentiate to all blood lineages. The strict …