Progress in identifying and understanding the molecular and cellular causes of cancer has
led to the discovery of anomalies that characterize cancer cells and that represent targets for …

The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family
that is abnormally activated in many epithelial tumors. Receptor activation leads to …

Much effort has been expended in the search for inhibitors of signalling molecules that may
prove to be important therapeutically in cancer. The epidermal growth factor receptor …

The epidermal growth factor receptor (EGFR) autocrine pathway contributes to a number of
processes important to cancer development and progression, including cell proliferation …

The ability of the epidermal growth factor receptor (EGFR) to transform epithelial cells, the
overexpression of EGFR and its ligands in several human carcinomas, and the causal …

Increasing knowledge of the structure and function of the epidermal growth factor receptor
(EGFR) subfamily of tyrosine kinases and of their role in the initiation and progression of …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is
frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as …

The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that
constitutes one of four members of the erbB family of tyrosine kinase receptors. Binding of …

Abstract Learning Objectives After completing this course, the reader will be able to: Explain
the molecular biology of epidermal growth factor receptor (EGFR) function in malignant cells …

The epidermal growth factor receptor (EGFR) is expressed in a wide variety of solid tumours.
It has been demonstrated that the EGFR-associated signaling pathway plays an important …