Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes,
and can accelerate diabetes-related microvascular and macrovascular complications by …

Background—Endothelial dysfunction contributes to the development of atherosclerosis in
patients with diabetes mellitus, but the mechanisms of endothelial dysfunction in this setting …

Mitochondria are highly dynamic organelles beyond powerhouses of a cell. These
components also play important roles in cell homeostasis by regulating cell function and …

Micro-and macrovascular complications are commonly seen in diabetic patients and
endothelial dysfunction contributes to the development and progression of the …

Mitochondrial dysfunction has been regarded as a hallmark of diabetic cardiomyopathy. In
addition to their canonical metabolic actions, mitochondria influence various other aspects of …

Endothelial cells (ECs) constitute the innermost layer in all blood vessels to maintain the
structural integrity and microcirculation function for coronary microvasculature. Impaired …

In diabetic cardiomyopathy (DCM), a major diabetic complication, the myocardium is
structurally and functionally altered without evidence of coronary artery disease …

The mitochondria are essential organelles that generate large amounts of ATP via the
electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species …

Mitochondria are key regulators of cell fate through controlling ATP generation and
releasing pro-apoptotic factors. Cardiac ischemia/reperfusion (I/R) injury to the coronary …

Diabetic cardiomyopathy and heart failure have been recognized as the leading causes of
mortality among diabetics. Diabetic cardiomyopathy has been characterized primarily by the …