Importance Human genetic studies have indicated that plasma lipoprotein (a)(Lp [a]) is
causally associated with the risk of coronary heart disease (CHD), but randomized trials of …

Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …

Lipoprotein (a)(Lp [a]) has gained attention as a heritable coronary artery disease (CAD) risk
factor and therapeutic target. Two genetic variants in the LPA gene have been reported to …

Recent published studies have provided increasing evidence that lipoprotein (a)[Lp (a)] may
be a potential causal, genetic, independent risk factor for cardiovascular disease (CVD). Lp …

High lipoprotein (a)[Lp (a)] concentrations are an independent risk factor for cardiovascular
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …

BACKGROUND: Both genome-wide association studies and candidate gene studies have
reported that the major determinant of plasma levels of the Lipoprotein (a)[Lp (a)] reside …

Background: The relationship of LPA single nucleotide polymorphisms (SNPs),
apolipoprotein (a) isoforms, and lipoprotein (a)[Lp (a)] levels with major adverse …

Background: Lipoprotein (a)(Lp [a]) is a circulating plasma lipoprotein that is emerging as an
important independent risk factor for vascular disease. Lp (a) levels are 75-90% heritable …

Background In recent years, lipoprotein (a)(Lp (a)) has been recognized as an important risk
factor for cardiovascular disease (CVD). A variant in the LPA gene, rs10455872, has been …

Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …