LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins

WQ Wei, X Li, Q Feng, M Kubo, IJ Kullo, PL Peissig… - Circulation, 2018 - Am Heart Assoc
Background: Coronary heart disease (CHD) is a leading cause of death globally. Although
therapy with statins decreases circulating levels of low-density lipoprotein cholesterol and …

Two rare variants explain association with acute myocardial infarction in an extended genomic region including the apolipoprotein (A) gene

W Koch, JC Mueller, M Schrempf… - Annals of Human …, 2013 - Wiley Online Library
Relatively low numbers of kringle 4 type 2 repeats in apolipoprotein (a) and specific
haplotypes of the SLC22A3‐LPAL2‐LPA region on chromosome 6 are associated with an …

Impact of apolipoprotein (a) isoform size on lipoprotein (a) lowering in the HPS2-THRIVE study

S Parish, JC Hopewell, MR Hill… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: Genetic studies have shown lipoprotein (a)(Lp [a]) to be an important causal
risk factor for coronary disease. Apolipoprotein (a) isoform size is the chief determinant of Lp …

LPA and PLG Sequence Variation and Kringle IV-2 Copy Number in Two Populations

DC Crawford, Z Peng, JF Cheng, D Boffelli, M Ahearn… - Human …, 2008 - karger.com
Abstract Background/Aims: Lp (a) levels have long been recognized as a potential risk factor
for coronary heart disease that is almost completely under genetic control. Much of the …

Eight reasons why lipoprotein (a) should be measured in everyone at least once in a lifetime

BJ Arsenault, PR Kamstrup - 2024 - academic.oup.com
Lipoprotein (a)[Lp (a)] is a highly atherogenic lipoprotein particle that may be found in high
concentrations in the blood of individuals who inherited Lp (a)-raising genetic variants. 1 …

Genetic and mechanistic insights into the modulation of circulating lipoprotein (a) concentration by apolipoprotein E isoforms

K Chemello, DJ Blom, AD Marais, G Lambert… - Current Atherosclerosis …, 2022 - Springer
Abstract Purpose of Review Lipoprotein (a)[Lp (a)] is a highly atherogenic lipoprotein
species. A unique feature of Lp (a) is the strong genetic determination of its concentration …

Burden of elevated lipoprotein (a) among patients with atherosclerotic cardiovascular disease: Evidence from a systematic literature review and feasibility assessment …

P Orfanos, AF Fonseca, X Hu, R Gautam… - PLoS …, 2023 - journals.plos.org
Background Elevated lipoprotein (a)[Lp (a)] level is an independent genetic risk factor that
increases the risk of atherosclerotic cardiovascular disease (ASCVD) by 2–4 fold. We aimed …

Genetically determined lipoprotein (a) levels do not cause an increased risk of preeclampsia-a two-sample Mendelian randomization study

M Golawski, M Lejawa, T Osadnik… - European Heart …, 2023 - academic.oup.com
Introduction High blood levels of lipoprotein (a)[Lp (a)] were suggested to increase the risk of
preeclampsia. Because excessive coagulation is involved in preeclampsia and Lp (a) is a …

Genetic control of lipoprotein (a) concentrations is different in Africans and Caucasians

M Scholz, HG Kraft, A Lingenhel, R Delport… - European Journal of …, 1999 - nature.com
Abstract Lipoprotein (a)(Lp (a)) represents a quantitative trait in human plasma associated
with atherothrombotic disease. Large variation in the distribution of Lp (a) concentrations …

Mechanisms of lipoprotein (a) pathogenicity: prothrombotic, proatherosclerotic, or both?

JD Spence, M Koschinsky - Arteriosclerosis, Thrombosis, and …, 2012 - Am Heart Assoc
(Arterioscler Thromb Vasc Biol. 2012; 32: 1550–1551.) angiographically, but carotid stenosis
(≥ 50%) was assessed by Doppler ultrasound, and peripheral vascular disease by …