Effect of vegetable and carotenoid consumption on aberrant crypt multiplicity, a surrogate end-point marker for colorectal cancer in azoxymethane-induced rats

PJ Rijken, WG Timmer, AJ van de Kooij… - …, 1999 - academic.oup.com
Epidemiological studies indicate that increased vegetable consumption reduces the risk of
colorectal cancer mortality. In the present study we have investigated the effect of …

Deguelin suppresses the formation of carcinogen‐induced aberrant crypt foci in the colon of CF‐1 mice

G Murillo, JW Kosmeder, JM Pezzuto… - International journal of …, 2003 - Wiley Online Library
Abstract Deguelin [(7aS, BaS)‐13, 13a‐dihydro‐9, 10‐dimethoxy‐3, 3‐dimethyl‐3H‐Bis [1]
benzopyrano [3, 4‐b: 6′, 5′‐e] pyran‐7 (7aH)‐one], a naturally occurring rotenone, has …

Inhibitory effect of Coptidis Rhizoma and Scutellariae Radix on azoxymethane-induced aberrant crypt foci formation in rat colon

M Fukutake, S Yokota, H Kawamura… - Biological and …, 1998 - jstage.jst.go.jp
抄録 This study was conducted t obtain effective cancer chemopreventive agents with low
toxicity from medicinal herbs. The effect of aqueous extracts from 9 medicinal herbs with anti …

Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia

EE Deschner, J Ruperto, G Wong… - …, 1991 - academic.oup.com
Dietary quercetin (QU) and rutin (RU), phenolic flavonoids commonly found in many fruits
and vegetables, were provided to CF1 female mice for 50 weeks to assess the ability of …

Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice

S Miyamoto, Y Yasui, H Ohigashi, T Tanaka… - Chemico-Biological …, 2010 - Elsevier
Obesity is known to be a risk factor for colon carcinogenesis. Although there are several
reports on the chemopreventive abilities of dietary flavonoids in chemically induced colon …

Retracted: Antiproliferative Efficacy of Hesperetin (Citrus Flavanoid) in 1,2‐Dimethylhydrazine‐Induced Colon Cancer

S Aranganathan, N Nalini - Phytotherapy Research, 2013 - Wiley Online Library
Cancer is the second leading cause of death worldwide and is increasing at an alarming
rate. The present study was to evaluate the antiproliferative effcts of hesperetin, a flavonoid …

Prevention of colon cancer and modulation of aberrant crypt foci, cell proliferation, and apoptosis by retinoids and NSAIDs

MA Pereira - Colon Cancer Prevention: Dietary Modulation of …, 1999 - Springer
Cancer is a multistage process involving multiple rare events with each suggesting a
mutational or chromosomal alteration. At the different steps along the progression to cancer …

Efficacy of garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 mice

G Murillo, UK CHOI, O Pan, AI Constantinou… - Anticancer …, 2004 - ar.iiarjournals.org
Background: Epidemiological studies have reported a low incidence of colon cancer in
countries with high legume consumption. Moreover, experimental studies have found that …

Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics

L Roncucci, M Pedroni, F Vaccina, P Benatti… - Cell …, 2000 - Wiley Online Library
Aberrant crypt foci (ACF) have been identified on the colonic mucosal surface of rodents
treated with colon carcinogens and of humans after methylene‐blue staining and …

Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane

Y Kishimoto, N Takata, T Jinnai, T Morisawa, G Shiota… - Gut, 2000 - gut.bmj.com
BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to
protect against the development of colon cancer. However, the mechanism (s) by which …