Acetylcholine (ACh) can act on pre-and post-synaptic muscarinic receptors (mAChR) in the
cortex to influence a myriad of cognitive processes. Two functionally-distinct regions of the …

Acetylcholine is a robust neuromodulator of the limbic system and a critical regulator of
arousal and emotions. The anterior cingulate cortex (ACC) and the amygdala (AMY) are key …

Acetylcholine (ACh) neurotransmission within the medial prefrontal cortex (mPFC) plays an
important modulatory role to support mPFC-dependent cognitive functions. This role is …

Acetylcholine (ACh) signaling shapes neuronal circuit development and underlies specific
aspects of cognitive functions and behaviors, including attention, learning, memory and …

Acetylcholine (ACh) promotes neocortical output to the thalamus and brainstem by
preferentially enhancing the postsynaptic excitability of layer 5 pyramidal tract (PT) neurons …

Rat and mouse models are widely used for studies in cognition and pathophysiology,
among others. Here, we sought to determine to what extent these two model species differ …

Acetylcholine (ACh) plays important roles for higher brain functions, including arousal,
attention, and cognition. These effects are mediated largely by muscarinic acetylcholine …

Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions
of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls …

While historically acetylcholine (ACh) holds a central place in the discovery of chemical
transmission in the nervous system, progress in our knowledge of the mechanistic …

Acetylcholine (ACh) is believed to underlie mechanisms of arousal and attention in
mammals. ACh also has a demonstrated functional effect in visual cortex that is both diverse …