While the free radical-generating enzyme xanthine oxidase is a central mechanism of injury
in postischemic tissues, questions remain regarding how xanthine oxidase-mediated radical …

The free radical-generating enzyme xanthine oxidase has been hypothesized to be a central
mechanism of the injury which occurs in postischemic tissues; however, its importance …

The xanthine oxidase pathway has been proposed as a source ofoxygen-derived free
radicals in ischemic and reperfused myocardium. A spectrophotometric assay was …

The enzyme xanthine oxidase has been implicated as a generator of toxic oxygen
metabolites that contribute to ischemic injury. Because substantial species variability has …

In the presence of its substrates hypoxanthine and xanthine, xanthine oxidase generates
oxygen free radicals that cause postischemic injury. Recently, it has been demonstrated that …

The reversible and irreversible conversion of xanthine dehydrogenase to xanthine oxidase
during ischemia/reperfusion and oxidative stress induced by hydrogen peroxide or diamide …

Myocardial ischemia initiates a series of cellular reactions which unless checked will
culminate in cell death and tissue necrosis. Although reperfusion provides a means of …

Using a highly specific assay that minimizes enzyme inactivation in vitro, we found that
rabbit myocardial tissue contained low levels of xanthine oxidase (XO) and xanthine …

Samples from four human hearts were analyzed for both their xanthine dehydrogenase and
xanthine oxidase content. We used the conventional spectrophotometric assay and a more …

Objective: Cardiac injury, related to ischaemia and reperfusion, may be caused by the action
of oxygen free radicals. Xanthine oxidoreductase activity may be an important free radical …