Despite partial sequence identity and structural similarity, human β-defensin 3 (HBD3) kills
Staphylococcus aureus with a 4-to 8-fold higher efficiency than human β-defensin 2 (HBD2) …

Antimicrobial peptides participate in the first line of defence of many organisms against
pathogens. In humans, the family of β-defensins plays a pivotal role in innate immunity. Two …

Human β-defensins (HBDs) are cationic antimicrobial peptides that are components of the
innate immune system. They are characterized by three disulfide bridges. However, the …

ABSTRACT Human β-defensin 3 (hBD3) is a highly basic 45-amino-acid protein that acts
both as an antimicrobial agent and as a chemoattractant molecule. Although the nature of its …

Human beta-defensins (hBDs) are crucial peptides for the innate immune response and are
thus prime candidates as therapeutic agents directed against infective diseases. Based on …

Human β-defensin 2 (hBD-2) is a 41-amino acid cationic peptide of the innate immune
system that serves as antimicrobial molecule. We determined the bactericidal activity of …

ABSTRACT β‐Defensins are antibiotic peptides involved in host defense at the epithelial
surface. Three human β‐defensins (hBDs)‐‐hBD‐1, hBD‐2, and hBD‐3‐‐have been …

The antibacterial activities of synthetic human β-defensin analogs, constrained by a single
disulfide bridge and in the reduced form, have been investigated. The peptides span the …

Human beta-defensins (hBDs) are antimicrobial peptides of human innate immunity. The
antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high …

Five variants of human β-defensins (HBDs) were expressed in Escherichia coli using two
vector systems (pET28a (+) and pQE30) with inducible expression by IPTG. The last vector …