Two new families of human farnesyltransferase inhibitors 13a–m and 14a–d, based on a
phenothiazine scaffold, were synthesized. Compounds 14a and 14b were the most …

A new series of phenothiazine and carbazole derivatives was synthesized and evaluated for
their biological activity on human protein farnesyltransferase. The farnesyltransferase …

Novel phenothiazine derivatives bearing an amino acid residue were synthesized via
peptide chemistry, and evaluated for their inhibitory potential on human farnesyltransferase …

The biological screening of the chemical library of our Organic Chemistry Department,
carried out on an automated fluorescence-based FTase assay, allowed us to discover that a …

A new family of protein farnesyltransferase inhibitors, based on a phenothiazine scaffold,
was designed and synthesized. The biological evaluation of these products showed that …

A new family of indolizine–chalcones was designed, synthesized and screened for the
inhibitory potential on human farnesyltransferase in vitro to identify potent antitumor agents …

A new family of CaaX competitive inhibitors of human farnesyltransferase based on
phenothiazine and carbazole skeleton bearing a l-cysteine, l-methionine, l-serine or l-valine …

A new family of 30 benzoylated N-ylides 4 and 5 was synthesized and evaluated for the
inhibitory activity on human protein farnesyltransferase. Most of these novel compounds …

Screening of the ICSN chemical library led to the discovery of 3-(4-chlorophenyl)-4-cyano-5-
thioalkylthiophene 2-carboxylic acids as potent farnesyltransferase inhibitors. Enzymatic …

Based on the structure of R115777 (tipifarnib, Zarnestra®), a series of farnesyltransferase
inhibitors have been synthesized by modification of the 2-quinolinone motif and …