PD-L1 expression in circulating tumor cells as a promising prognostic biomarker in advanced non–small-cell lung cancer treated with immune checkpoint inhibitors

FG Dall'Olio, F Gelsomino, N Conci, L Marcolin… - Clinical Lung Cancer, 2021 - Elsevier
Abstract Background Circulating tumor cells (CTCs) are a promising source of biological
information in cancer. Data correlating PD-L1 expression in CTCs with patients' response to …

PD-L1 expression as a predictive biomarker in advanced non-small-cell lung cancer: updated survival data

PN Aguiar Jr, RA De Mello, P Hall, H Tadokoro… - …, 2017 - Taylor & Francis
Aim The treatment of non-small-cell lung cancer has changed after the development of the
immune checkpoint inhibitors. Although the most studied biomarker is PD-L1 expression, its …

Circulating tumor cells PD‐L1 expression detection and correlation of therapeutic efficacy of immune checkpoint inhibition in advanced non‐small‐cell lung cancer

Q Zhou, X Liu, J Li, B Tong, Y Xu, M Chen… - Thoracic …, 2023 - Wiley Online Library
Introduction This study investigated whether programmed death‐ligand 1 (PD‐L1)
expression of circulating tumor cells (CTCs) in peripheral blood can serve as a predictive …

Circulating tumor cell PD-L1 expression as biomarker for therapeutic efficacy of immune checkpoint inhibition in NSCLC

V Kloten, R Lampignano, T Krahn, T Schlange - Cells, 2019 - mdpi.com
Over the last decade, the immune checkpoint blockade targeting the programmed death
protein 1 (PD-1)/programmed death ligand 1 (PD-L1) axis has improved progression-free …

Clinical roles of soluble PD-1 and PD-L1 in plasma of NSCLC patients treated with immune checkpoint inhibitors

H Himuro, Y Nakahara, Y Igarashi, T Kouro… - Cancer Immunology …, 2023 - Springer
Abstract Introduction Immune checkpoint inhibitors (ICIs) have significantly improved the
prognosis of non-small cell lung cancer (NSCLC). However, only a limited proportion of …

PD-L1 expression in non-small cell lung cancer specimens: association with clinicopathological factors and molecular alterations

MSI Mansour, K Malmros, U Mager… - International Journal of …, 2022 - mdpi.com
Immune checkpoint inhibitors (ICI) targeting programmed cell death-1 or its ligand (PD-L1)
have improved outcomes in non-small cell lung cancer (NSCLC). High tumor PD-L1 …

Novel biomarkers of dynamic blood PD-L1 expression for immune checkpoint inhibitors in advanced non-small-cell lung cancer patients

Q Yang, M Chen, J Gu, K Niu, X Zhao, L Zheng… - Frontiers in …, 2021 - frontiersin.org
Background Immune checkpoint inhibitors (ICIs) have become a high-profile regimen for
malignancy recently. However, only a small subpopulation obtains long-term clinical benefit …

PD-L1 expression in systemic immune cell populations as a potential predictive biomarker of responses to PD-L1/PD-1 blockade therapy in lung cancer

A Bocanegra, G Fernandez-Hinojal… - International journal of …, 2019 - mdpi.com
PD-L1 tumor expression is a widely used biomarker for patient stratification in PD-L1/PD-1
blockade anticancer therapies, particularly for lung cancer. However, the reliability of this …

The significance of the PD-L1 expression in non–small-cell lung cancer: trenchant double swords as predictive and prognostic markers

K Takada, G Toyokawa, F Shoji, T Okamoto… - Clinical lung cancer, 2018 - Elsevier
Lung cancer is the leading cause of death due to cancer worldwide. Surgery, chemotherapy,
and radiotherapy have been the standard treatment for lung cancer, and targeted molecular …

PD-L1 expression in circulating tumor cells of advanced non-small cell lung cancer patients treated with nivolumab

N Guibert, M Delaunay, A Lusque, N Boubekeur… - Lung Cancer, 2018 - Elsevier
Background Inhibitors of the PD-1/PD-L1 immune checkpoint have become a standard of
care in non-small cell lung cancer (NSCLC). Patient selection, currently based on PD-L1 …