Bromodomains are critical components of many chromatin modifying/remodelling proteins
and are emerging therapeutic targets, yet how they interact with nucleosomes, rather than …

Foreword Tost, Gay & Firestein tions. In this issue, Reedquist and colleagues summarize the
current state of knowledge on changes in histone acetylation in rheumatoid arthritis [5]. This …

The bromodomains and extra-terminal domain (BET) family proteins recognize acetylated
chromatin through their bromodomains (BDs) and help in regulating gene expression. BDs …

Bromodomains are epigenetic readers of histone acetylation involved in chromatin
remodeling and transcriptional regulation. The human proteome comprises 46 …

Lysine acetylation is an important epigenetic mark regulating gene transcription and
chromatin structure. Acetylated lysine residues are specifically recognized by …

Histone modifications are important for maintaining the transcription program. BET proteins,
an important class of “histone reading proteins”, have recently been described as essential …

Orchestration of the inflammatory response is crucial for clearing pathogens. Although the
production of multiple inflammatory cytokines has been thought to be regulated by common …

Bromodomain and extraterminal (BET) proteins are essential to pro-inflammatory gene
transcription. The BET family proteins, BRD2, BRD3, BRD4, and testis-specific BRDT …

Chromatin remodeling, and a persistent histone 3 lysine 27 acetylation (H3K27ac) in
particular, are associated with a sustained inflammatory response of synovial fibroblasts …

Acetylation of histone is a key epigenetic modification, and contributes to many DNA-
dependent cellular processes. The bromodomain structure, which consists of approximately …