Handbook of Animal Models of Infection is a complete revision of a three-volume text that
was published in 1986. It incorporates the major advances in the field during the past …

The testing of potential antimicrobial agents in animal models of infectious disease is a long-
established practice and is acknowledged asan essential prerequisite of antiinfective …

The use of animal models has become an integral part of the evaluation of drugs for
antimicrobial chemotherapy. Animal models can be used to define the penetration of …

Animal models of infection have had a prominent place in the evaluation of infection and its
treatment. From early experiments demonstrating transmission of infectious agents to satisfy …

Animal models have contributed substantially to unravelling the physiopathology of infection
and hostepathogen interactions in infectious diseases. Experimental studies on animals …

Animal models of infection should be considered as tools that may be used for many
different purposes: investigation of the physiopathology and natural history of infection on …

The interactions between microbes and antimicrobial agents in vitro are often markedly
different from those in vivo, presumably because of pharmacological factors and host …

Animal models have proven to be invaluable in bridging the gap between in vitro
susceptibility testing of an antibiotic and anticipating results obtained in clinical studies …

Experimental infection models have long been recognized as an essential part of testing anti-
infective therapies. A perfect animal model would be a model that satisfied not only scientific …

The advent of several new antibiotics able to counter drug-resistant bacteria, the problems in
carrying out well-controlled clinical trials and the occasional disparity between in vitro and in …