Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials

A Lotfy, NM AboQuella, H Wang - Stem Cell Research & Therapy, 2023 - Springer
Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their
robust immunomodulatory and regenerative properties. Their paracrine activity is one of the …

Therapeutic features and updated clinical trials of mesenchymal stem cell (MSC)-derived exosomes

BC Lee, I Kang, KR Yu - Journal of clinical medicine, 2021 - mdpi.com
Identification of the immunomodulatory and regenerative properties of mesenchymal stem
cells (MSCs) have made them an attractive alternative therapeutic option for diseases with …

Preclinical translation of exosomes derived from mesenchymal stem/stromal cells

FM Elahi, DG Farwell, JA Nolta, JD Anderson - Stem cells, 2020 - academic.oup.com
Exosomes are nanovesicles secreted by virtually all cells. Exosomes mediate the horizontal
transfer of various macromolecules previously believed to be cell-autonomous in nature …

New therapeutic approaches of mesenchymal stem cells-derived exosomes

J Janockova, L Slovinska, D Harvanova… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem cells (MSCs) have been demonstrated to have a great potential in the
treatment of several diseases due to their differentiation and immunomodulatory capabilities …

Mesenchymal stem cell-derived exosomes for clinical use

M Mendt, K Rezvani, E Shpall - Bone marrow transplantation, 2019 - nature.com
Mesenchymal stem/stromal cells (MSCs) are commonly used as a source of cellular therapy
due to their strong immunosuppressive and regenerative effects. One of the key …

Challenges and strategies: scalable and efficient production of mesenchymal stem cells-derived exosomes for cell-free therapy

W Pan, H Chen, A Wang, F Wang, X Zhang - Life sciences, 2023 - Elsevier
Exosomes are small membrane vesicles secreted by most cell types, and widely exist in cell
supernatants and various body fluids. They can transmit numerous bioactive elements, such …

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

S Nikfarjam, J Rezaie, NM Zolbanin, R Jafari - Journal of translational …, 2020 - Springer
Mesenchymal stem cells (MSCs) have captured great attention in regenerative medicine for
over a few decades by virtue of their differentiation capacity, potent immunomodulatory …

Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm

K Yin, S Wang, RC Zhao - Biomarker research, 2019 - Springer
Mesenchymal stem/stromal cells (MSCs) have been demonstrated to hold great potential for
the treatment of several diseases. Their therapeutic effects are largely mediated by …

[HTML][HTML] Therapeutic use of mesenchymal stem cell-derived exosomes: from basic science to clinics

CR Harrell, N Jovicic, V Djonov, V Volarevic - Pharmaceutics, 2020 - mdpi.com
Mesenchymal stem cells (MSC) are, due to their immunosuppressive and regenerative
properties, used as new therapeutic agents in cell-based therapy of inflammatory and …

Exosome: a novel and safer therapeutic refinement of mesenchymal stem cell

RWY Yeo, RC Lai, KH Tan… - Exosomes and …, 2013 - journals.sagepub.com
Mesenchymal stem cell (MSC) has just been approved as the first “off-the-shelf” stem cell
pharmaceutical drug with an anticipation of more approvals following completion of …