Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular
mechanisms underlying nuclear transport that involve the nuclear transport receptor, small …

In eukaryotic cells, cell functions are maintained in an orderly manner through the
continuous traffic of various proteins between the cell nucleus and the cytoplasm. The …

抄録 The active transport of proteins into and out of the nucleus is mediated by specific
signals, the nuclear localzation signal (NLS) and nuclear export signal (NES), respectively …

The nuclear export of importin-α is mediated by CAS, which is related to importin-β, whereas
the mechanism for the export of importin-β remains unclear. In this study, we demonstrate …

▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …

Background: Selective protein import into the cell nucleus occurs in two steps: binding to the
nuclear envelope, followed by energy-dependent transit through the nuclear pore complex …

Importin α performs the indispensable role of ferrying proteins from the cytoplasm into the
nucleus with a transport carrier, importin β1. Mammalian cells from mouse or human contain …

The evolution of the nucleus imposed on eukaryotic cells the necessity to strictly control
exchange of molecules between the nucleus and the remainder of the cell, not only to …

Proteins to be transported into the nucleus are recognized by members of the importin-
karyopherin nuclear transport receptor family. After docking at the nuclear pore complex …

The importin α/β heterodimer targets hundreds of proteins to the nuclear-pore complex
(NPC) and facilitates their translocation across the nuclear envelope. Importin α binds to …