One of the most prominent features of secondary hyperalgesia is touch-evoked pain, ie, pain
evoked by dynamic tactile stimuli applied to areas adjacent or remote from the originating …

Long-term potentiation (LTP) is the key cellular mechanism for physiological learning and
pathological chronic pain. In the anterior cingulate cortex (ACC), postsynaptic recruitment or …

Background: Tissue injury elicits both hypersensitivity to evoked stimuli and ongoing,
stimulus-independent pain. We previously demonstrated that pain relief elicits reward in …

It is conceivable that plasticity in pain control systems and chronic pain may be due to
mechanisms similar to learning. Long-term potentiation (LTP) in the hippocampus is often …

Systemic administration of analgesics can lead to serious adverse side effects
compromising therapeutic benefit in some patients. Information coding pain transmits along …

Background We previously reported that intrathecal injection of lysophosphatidylcholine
(LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 …

The mechanisms that lead to the maintenance of chronic pain states are poorly understood,
but their elucidation could lead to new insights into how pain becomes chronic and how it …

Transient receptor potential vanilloid (TRPV1) receptors are abundant in a subpopulation of
primary sensory neurons that convey nociceptive information from the periphery to the spinal …

Advances in the characterization of pain signaling in recent years indicate that distinct
neurophysiological and neurochemical mechanisms contribute to pain arising from injury to …

Since the discovery of NMDA receptor (NMDAR) dependent long-term potentiation (LTP) in
the hippocampus, many studies have demonstrated that NMDAR dependent LTP exists …